Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells

Serena Mazzucchelli; Miriam Colombo; Paolo Verderio; Ewa Rozek; Francesco Andreata; Elisabetta Galbiati; Paolo Tortora; Fabio Corsi; Davide Prosperi

doi:10.1002/anie.201209662

Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells

Serena Mazzucchelli, Miriam Colombo, Paolo Verderio, Ewa Rozek, Francesco Andreata, Elisabetta Galbiati, Paolo Tortora, Fabio Corsi, Davide Prosperi

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells.

Original language	English
Pages (from-to)	3121-3125
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	11
DOIs	https://doi.org/10.1002/anie.201209662
Publication status	Published - Mar 11 2013

Keywords

bioconjugation
cell targeting
nanoparticles
peptides
receptors

ASJC Scopus subject areas

Chemistry(all)
Catalysis

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Mazzucchelli, S., Colombo, M., Verderio, P., Rozek, E., Andreata, F., Galbiati, E., Tortora, P., Corsi, F., & Prosperi, D. (2013). Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells. Angewandte Chemie - International Edition, 52(11), 3121-3125. https://doi.org/10.1002/anie.201209662

Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells. / Mazzucchelli, Serena; Colombo, Miriam; Verderio, Paolo; Rozek, Ewa; Andreata, Francesco; Galbiati, Elisabetta; Tortora, Paolo; Corsi, Fabio; Prosperi, Davide.

In: Angewandte Chemie - International Edition, Vol. 52, No. 11, 11.03.2013, p. 3121-3125.

Research output: Contribution to journal › Article › peer-review

Mazzucchelli, S, Colombo, M, Verderio, P, Rozek, E, Andreata, F, Galbiati, E, Tortora, P, Corsi, F & Prosperi, D 2013, 'Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells', Angewandte Chemie - International Edition, vol. 52, no. 11, pp. 3121-3125. https://doi.org/10.1002/anie.201209662

Mazzucchelli, Serena ; Colombo, Miriam ; Verderio, Paolo ; Rozek, Ewa ; Andreata, Francesco ; Galbiati, Elisabetta ; Tortora, Paolo ; Corsi, Fabio ; Prosperi, Davide. / Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 11. pp. 3121-3125.

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