Abstract
In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells.
Original language | English |
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Pages (from-to) | 3121-3125 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 11 |
DOIs | |
Publication status | Published - Mar 11 2013 |
Keywords
- bioconjugation
- cell targeting
- nanoparticles
- peptides
- receptors
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis