Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells

Serena Mazzucchelli, Miriam Colombo, Paolo Verderio, Ewa Rozek, Francesco Andreata, Elisabetta Galbiati, Paolo Tortora, Fabio Corsi, Davide Prosperi

Research output: Contribution to journalArticlepeer-review

Abstract

In control: The ligand positioning and orientation on multifunctional nanoparticles (MNP) are controlled by using a versatile bimodular approach that exploits an 11 amino acid (U11) homing peptide genetically fused with a haloalkane dehalogenase (HALO) enzyme. The resultant nanoparticles have good targeting efficiency and selectivity toward broadly occurring urokinase plasminogen activator receptor positive human cancer cells.

Original languageEnglish
Pages (from-to)3121-3125
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number11
DOIs
Publication statusPublished - Mar 11 2013

Keywords

  • bioconjugation
  • cell targeting
  • nanoparticles
  • peptides
  • receptors

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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