Abstract
Africa is one of the endemic regions of HBV infection. In particular, genotype E is highly endemic in most of sub-Saharan Africa such as West African countries where it represents more than 90% of total infections. Madagascar, which is classified as a high endemic area for HBV and where the most prevalent genotype is E, might play a relevant role in the dispersion of this genotype due to its crucial position in the Indian Ocean. The aim of this study was to investigate the origin, population dynamics, and circulation of HBV-E genotype in Madagascar through high-resolution phylogenetic and phylodynamic approaches. The phylogenetic tree indicated that Malagasy isolates were intermixed and closely related with sequences mostly from West African countries. The Bayesian tree highlighted three statistically supported clusters of Malagasy strains which dated back to the years 1981 (95% HPD: 1971–1992), 1986 (95% HPD: 1974–1996), and 1989 (95% HPD: 1974–2001). Population dynamics analysis showed an exponential increase in the number of HBV-E infections approximately from the year 1975 until 2000s. The migration analysis was also performed and a dynamic pattern of gene flow was identified. In conclusion, this study confirms previous observation of HBV-E circulation in Africa and expands these findings at Madagascar demonstrating its recent introduction, and highlighting the role of the African countries in the spread of HBV-E genotype. Further studies on molecular epidemiology of HBV genotype E are needed to clarify the evolutionary history of this genotype.
| Original language | English |
|---|---|
| Pages (from-to) | 23-30 |
| Number of pages | 8 |
| Journal | Pathogens and Global Health |
| Volume | 111 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2 2017 |
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Keywords
- Hepatitis B virus
- Madagascar
- migration analysis
- phylodynamics
- phylogeny
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar. / Lo Presti, Alessandra; Andriamandimby, Soa Fy; Lai, Alessia; Angeletti, Silvia; Cella, Eleonora; Mottini, Giovanni; Guarino, Michele Pier Luca; Balotta, Claudia; Galli, Massimo; Heraud, Jean Michel; Zehender, Gianguglielmo; Ciccozzi, Massimo.
In: Pathogens and Global Health, Vol. 111, No. 1, 02.01.2017, p. 23-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar
AU - Lo Presti, Alessandra
AU - Andriamandimby, Soa Fy
AU - Lai, Alessia
AU - Angeletti, Silvia
AU - Cella, Eleonora
AU - Mottini, Giovanni
AU - Guarino, Michele Pier Luca
AU - Balotta, Claudia
AU - Galli, Massimo
AU - Heraud, Jean Michel
AU - Zehender, Gianguglielmo
AU - Ciccozzi, Massimo
PY - 2017/1/2
Y1 - 2017/1/2
N2 - Africa is one of the endemic regions of HBV infection. In particular, genotype E is highly endemic in most of sub-Saharan Africa such as West African countries where it represents more than 90% of total infections. Madagascar, which is classified as a high endemic area for HBV and where the most prevalent genotype is E, might play a relevant role in the dispersion of this genotype due to its crucial position in the Indian Ocean. The aim of this study was to investigate the origin, population dynamics, and circulation of HBV-E genotype in Madagascar through high-resolution phylogenetic and phylodynamic approaches. The phylogenetic tree indicated that Malagasy isolates were intermixed and closely related with sequences mostly from West African countries. The Bayesian tree highlighted three statistically supported clusters of Malagasy strains which dated back to the years 1981 (95% HPD: 1971–1992), 1986 (95% HPD: 1974–1996), and 1989 (95% HPD: 1974–2001). Population dynamics analysis showed an exponential increase in the number of HBV-E infections approximately from the year 1975 until 2000s. The migration analysis was also performed and a dynamic pattern of gene flow was identified. In conclusion, this study confirms previous observation of HBV-E circulation in Africa and expands these findings at Madagascar demonstrating its recent introduction, and highlighting the role of the African countries in the spread of HBV-E genotype. Further studies on molecular epidemiology of HBV genotype E are needed to clarify the evolutionary history of this genotype.
AB - Africa is one of the endemic regions of HBV infection. In particular, genotype E is highly endemic in most of sub-Saharan Africa such as West African countries where it represents more than 90% of total infections. Madagascar, which is classified as a high endemic area for HBV and where the most prevalent genotype is E, might play a relevant role in the dispersion of this genotype due to its crucial position in the Indian Ocean. The aim of this study was to investigate the origin, population dynamics, and circulation of HBV-E genotype in Madagascar through high-resolution phylogenetic and phylodynamic approaches. The phylogenetic tree indicated that Malagasy isolates were intermixed and closely related with sequences mostly from West African countries. The Bayesian tree highlighted three statistically supported clusters of Malagasy strains which dated back to the years 1981 (95% HPD: 1971–1992), 1986 (95% HPD: 1974–1996), and 1989 (95% HPD: 1974–2001). Population dynamics analysis showed an exponential increase in the number of HBV-E infections approximately from the year 1975 until 2000s. The migration analysis was also performed and a dynamic pattern of gene flow was identified. In conclusion, this study confirms previous observation of HBV-E circulation in Africa and expands these findings at Madagascar demonstrating its recent introduction, and highlighting the role of the African countries in the spread of HBV-E genotype. Further studies on molecular epidemiology of HBV genotype E are needed to clarify the evolutionary history of this genotype.
KW - Hepatitis B virus
KW - Madagascar
KW - migration analysis
KW - phylodynamics
KW - phylogeny
UR - http://www.scopus.com/inward/record.url?scp=85010647602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010647602&partnerID=8YFLogxK
U2 - 10.1080/20477724.2016.1278103
DO - 10.1080/20477724.2016.1278103
M3 - Article
C2 - 28081689
AN - SCOPUS:85010647602
VL - 111
SP - 23
EP - 30
JO - Pathogens and Global Health
JF - Pathogens and Global Health
SN - 2047-7724
IS - 1
ER -