Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar

Alessandra Lo Presti, Soa Fy Andriamandimby, Alessia Lai, Silvia Angeletti, Eleonora Cella, Giovanni Mottini, Michele Pier Luca Guarino, Claudia Balotta, Massimo Galli, Jean Michel Heraud, Gianguglielmo Zehender, Massimo Ciccozzi

Research output: Contribution to journalArticle

Abstract

Africa is one of the endemic regions of HBV infection. In particular, genotype E is highly endemic in most of sub-Saharan Africa such as West African countries where it represents more than 90% of total infections. Madagascar, which is classified as a high endemic area for HBV and where the most prevalent genotype is E, might play a relevant role in the dispersion of this genotype due to its crucial position in the Indian Ocean. The aim of this study was to investigate the origin, population dynamics, and circulation of HBV-E genotype in Madagascar through high-resolution phylogenetic and phylodynamic approaches. The phylogenetic tree indicated that Malagasy isolates were intermixed and closely related with sequences mostly from West African countries. The Bayesian tree highlighted three statistically supported clusters of Malagasy strains which dated back to the years 1981 (95% HPD: 1971–1992), 1986 (95% HPD: 1974–1996), and 1989 (95% HPD: 1974–2001). Population dynamics analysis showed an exponential increase in the number of HBV-E infections approximately from the year 1975 until 2000s. The migration analysis was also performed and a dynamic pattern of gene flow was identified. In conclusion, this study confirms previous observation of HBV-E circulation in Africa and expands these findings at Madagascar demonstrating its recent introduction, and highlighting the role of the African countries in the spread of HBV-E genotype. Further studies on molecular epidemiology of HBV genotype E are needed to clarify the evolutionary history of this genotype.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalPathogens and Global Health
Volume111
Issue number1
DOIs
Publication statusPublished - Jan 2 2017

Fingerprint

Madagascar
Hepatitis B virus
Genotype
Population Dynamics
Virus Diseases
Indian Ocean
Gene Flow
Molecular Epidemiology
Africa South of the Sahara
History
Observation
Infection

Keywords

  • Hepatitis B virus
  • Madagascar
  • migration analysis
  • phylodynamics
  • phylogeny

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Lo Presti, A., Andriamandimby, S. F., Lai, A., Angeletti, S., Cella, E., Mottini, G., ... Ciccozzi, M. (2017). Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar. Pathogens and Global Health, 111(1), 23-30. https://doi.org/10.1080/20477724.2016.1278103

Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar. / Lo Presti, Alessandra; Andriamandimby, Soa Fy; Lai, Alessia; Angeletti, Silvia; Cella, Eleonora; Mottini, Giovanni; Guarino, Michele Pier Luca; Balotta, Claudia; Galli, Massimo; Heraud, Jean Michel; Zehender, Gianguglielmo; Ciccozzi, Massimo.

In: Pathogens and Global Health, Vol. 111, No. 1, 02.01.2017, p. 23-30.

Research output: Contribution to journalArticle

Lo Presti, A, Andriamandimby, SF, Lai, A, Angeletti, S, Cella, E, Mottini, G, Guarino, MPL, Balotta, C, Galli, M, Heraud, JM, Zehender, G & Ciccozzi, M 2017, 'Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar', Pathogens and Global Health, vol. 111, no. 1, pp. 23-30. https://doi.org/10.1080/20477724.2016.1278103
Lo Presti, Alessandra ; Andriamandimby, Soa Fy ; Lai, Alessia ; Angeletti, Silvia ; Cella, Eleonora ; Mottini, Giovanni ; Guarino, Michele Pier Luca ; Balotta, Claudia ; Galli, Massimo ; Heraud, Jean Michel ; Zehender, Gianguglielmo ; Ciccozzi, Massimo. / Origin and evolutionary dynamics of Hepatitis B virus (HBV) genotype E in Madagascar. In: Pathogens and Global Health. 2017 ; Vol. 111, No. 1. pp. 23-30.
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