Origin and genetic background of insulinomas

Guido Rindi, M. E. Candusso, A. L. Marchetti

Research output: Contribution to journalArticlepeer-review


Insulin-producing B cell tumors (insulinomas) are the most frequent functioning endocrine tumors of the pancreas. Available experimental evidence suggests that the islet B cell is the most likely cell of origin of insulinomas, while the duct endocrine cell should be considered if rearrangement of the pancreatic parenchyma occurs. Data on the genetic background of insulinomas suggest that the B cell tumor development may result from alteration of several genes, including the multiple endocrine neoplasia type 1 (MEN1) gene.

Original languageEnglish
Pages (from-to)283-290
Number of pages8
JournalEndocrine Pathology
Issue number4
Publication statusPublished - 1999


  • Endocrine cells
  • Genetics
  • Insulinoma
  • Pancreas

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pathology and Forensic Medicine


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