Abstract
Insulin-producing B cell tumors (insulinomas) are the most frequent functioning endocrine tumors of the pancreas. Available experimental evidence suggests that the islet B cell is the most likely cell of origin of insulinomas, while the duct endocrine cell should be considered if rearrangement of the pancreatic parenchyma occurs. Data on the genetic background of insulinomas suggest that the B cell tumor development may result from alteration of several genes, including the multiple endocrine neoplasia type 1 (MEN1) gene.
Original language | English |
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Pages (from-to) | 283-290 |
Number of pages | 8 |
Journal | Endocrine Pathology |
Volume | 10 |
Issue number | 4 |
Publication status | Published - 1999 |
Keywords
- Endocrine cells
- Genetics
- Insulinoma
- Pancreas
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Pathology and Forensic Medicine