Origin, phenotype and function of human natural killer cells in pregnancy

Paola Vacca, Lorenzo Moretta, Alessandro Moretta, Maria Cristina Mingari

Research output: Contribution to journalArticle

Abstract

During the early phases of pregnancy, natural killer (NK) cells are the predominant lymphoid cells in the human decidua. Here, rather than act as killers and/or drivers of inflammation, NK cells contribute to tissue building and remodeling and formation of new vessels due to the release of interleukin-8, vascular endothelial growth factor, stromal cell-derived factor-1 and interferon gamma-inducible protein-10. Here, we propose that the interaction of NK cells with CD14 + myelomonocytic cells to promote induction of T regulatory cells plays a pivotal role in immunosuppression and tolerance towards the fetus allograft. Importantly, CD34 + hematopoietic precursors are present in human decidua and may give rise to decidual NK cells. Defects in decidual NK cell generation, or in appropriate functional interactions with other cell types, could have major consequences for successful pregnancy.

Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalTrends in Immunology
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 2011

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Natural Killer Cells
Phenotype
Pregnancy
Decidua
Chemokine CXCL10
Chemokine CXCL12
Regulatory T-Lymphocytes
Interleukin-8
Immunosuppression
Vascular Endothelial Growth Factor A
Interferon-gamma
Allografts
Fetus
Lymphocytes
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Origin, phenotype and function of human natural killer cells in pregnancy. / Vacca, Paola; Moretta, Lorenzo; Moretta, Alessandro; Mingari, Maria Cristina.

In: Trends in Immunology, Vol. 32, No. 11, 11.2011, p. 517-523.

Research output: Contribution to journalArticle

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