Abstract
During the early phases of pregnancy, natural killer (NK) cells are the predominant lymphoid cells in the human decidua. Here, rather than act as killers and/or drivers of inflammation, NK cells contribute to tissue building and remodeling and formation of new vessels due to the release of interleukin-8, vascular endothelial growth factor, stromal cell-derived factor-1 and interferon gamma-inducible protein-10. Here, we propose that the interaction of NK cells with CD14 + myelomonocytic cells to promote induction of T regulatory cells plays a pivotal role in immunosuppression and tolerance towards the fetus allograft. Importantly, CD34 + hematopoietic precursors are present in human decidua and may give rise to decidual NK cells. Defects in decidual NK cell generation, or in appropriate functional interactions with other cell types, could have major consequences for successful pregnancy.
| Original language | English |
|---|---|
| Pages (from-to) | 517-523 |
| Number of pages | 7 |
| Journal | Trends in Immunology |
| Volume | 32 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2011 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Origin, phenotype and function of human natural killer cells in pregnancy. / Vacca, Paola; Moretta, Lorenzo; Moretta, Alessandro; Mingari, Maria Cristina.
In: Trends in Immunology, Vol. 32, No. 11, 11.2011, p. 517-523.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Origin, phenotype and function of human natural killer cells in pregnancy
AU - Vacca, Paola
AU - Moretta, Lorenzo
AU - Moretta, Alessandro
AU - Mingari, Maria Cristina
PY - 2011/11
Y1 - 2011/11
N2 - During the early phases of pregnancy, natural killer (NK) cells are the predominant lymphoid cells in the human decidua. Here, rather than act as killers and/or drivers of inflammation, NK cells contribute to tissue building and remodeling and formation of new vessels due to the release of interleukin-8, vascular endothelial growth factor, stromal cell-derived factor-1 and interferon gamma-inducible protein-10. Here, we propose that the interaction of NK cells with CD14 + myelomonocytic cells to promote induction of T regulatory cells plays a pivotal role in immunosuppression and tolerance towards the fetus allograft. Importantly, CD34 + hematopoietic precursors are present in human decidua and may give rise to decidual NK cells. Defects in decidual NK cell generation, or in appropriate functional interactions with other cell types, could have major consequences for successful pregnancy.
AB - During the early phases of pregnancy, natural killer (NK) cells are the predominant lymphoid cells in the human decidua. Here, rather than act as killers and/or drivers of inflammation, NK cells contribute to tissue building and remodeling and formation of new vessels due to the release of interleukin-8, vascular endothelial growth factor, stromal cell-derived factor-1 and interferon gamma-inducible protein-10. Here, we propose that the interaction of NK cells with CD14 + myelomonocytic cells to promote induction of T regulatory cells plays a pivotal role in immunosuppression and tolerance towards the fetus allograft. Importantly, CD34 + hematopoietic precursors are present in human decidua and may give rise to decidual NK cells. Defects in decidual NK cell generation, or in appropriate functional interactions with other cell types, could have major consequences for successful pregnancy.
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UR - http://www.scopus.com/inward/citedby.url?scp=82455210781&partnerID=8YFLogxK
U2 - 10.1016/j.it.2011.06.013
DO - 10.1016/j.it.2011.06.013
M3 - Article
C2 - 21889405
AN - SCOPUS:82455210781
VL - 32
SP - 517
EP - 523
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 11
ER -