Original Articles: Bladder Cancer: A New Approach Using Local Combined Microwave Hyperthermia and Chemotherapy in Superficial Transitional Bladder Carcinoma Treatment

Renzo Colombo, Avigdor Lev, Luigi F. Da Pozzo, Massimo Freschi, Giuseppe Gallus, Patrizio Rigatti

Research output: Contribution to journalArticlepeer-review

Abstract

For some time hyperthermia, alone or in combination with radiotherapy or chemotherapy, has proved to be a promising method for treating several kinds of solid tumors. After intensive laboratory investigations a new device, based on a microwave source delivering local bladder hyperthermia together with intravesical mitomycin C chemotherapy has been clinically tested as a neoadjuvant approach in 44 patients suffering from superficial cancer of the bladder. The combined approach was administered on an outpatient basis without major complications and with acceptable local toxicity. Endoscopic and histological evaluations proved that combined local hyperthermia and chemotherapy can induce necrosis of transitional tumors. The overall response rate was 90.8%, with 70.4% complete and 20.4% partial, leaving 4 patients (9.2%) nonrespondent. Clinical and histological evaluations have confirmed the feasibility and safety of this combined treatment. Further multicentric studies have been initiated.

Original languageEnglish
Pages (from-to)959-963
Number of pages5
JournalJournal of Urology
Volume153
Issue number3 SUPPL.
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Urology

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