Original papers: Detection and further characterization of a newly described microsomal autoantibody associated with chronic delta infection

Francesco Caredda, Giovanni De Bartolo, Luisa Zampini, Wilma Barcellini, Claudio Zayaglia, Graziella Carella, Pier Luigi Meroni

Research output: Contribution to journalArticle

Abstract

Sera from 162 patients with acute or chronic hepatitis and from patients with autoimmune diseases have been investigated for autoantibodies by indirect immunofluorescence on human and animal tissues. A small proportion (14.2%) of young patients with chronic δ hepatitis has been found positive for cytoplasmic staining which was maximal in hepatocytes and renal proximal tubules. This autoantibody has been found to react with microsomal antigenic determinant different from the classic liver-kidney microsomal LKM antigen as demonstrated by fluorescence absorption experiments with purified subcellular organelles and by fluorescence-blocking tests. The microsomal autoantibody displayed also organ and species-specificity different from those shown by the LKM-positive sera. The positive patients showed persistence of the microsomal autoantibody during the follow-up without other serological markers of autoimmunity. There was no evidence of a particular course of chronic δ hepatitis in patients positive for the microsomal autoantibody.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalDigestion
Volume33
Issue number4
DOIs
Publication statusPublished - 1986

Keywords

  • Autoantibodies
  • Delta infection
  • Microsomal autoantibody

ASJC Scopus subject areas

  • Gastroenterology

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