Origins and clinical implications of the brain tumor stem cell hypothesis

Hasan A. Zaidi, Thomas Kosztowski, Francesco DiMeco, Alfredo Quiñones-Hinojosa

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

With the advent of the cancer stem cell hypothesis, the field of cancer research has experienced a revolution in how we think of and approach cancer. The discovery of "brain tumor stem cells" has offered an explanation for several long-standing conundrums on why brain tumors behave the way they do to treatment. Despite the great amount of research that has been done in order to understand the molecular aspects of malignant gliomas, the prognosis of brain tumors remains dismal. The slow progress in extending the survival of patients with malignant CNS neoplasms is very likely due to poor understanding of the cell of origin in these tumors. This review article discusses the progress in our understanding of brain tumor stem cells as the cell of origin in brain cancers. We review the different proposed mechanisms of how brain tumor stem cells may originate, the intracellular pathways disrupted in the pathogenesis of BTSCs, the molecular markers used to identify BTSCs, the molecular mechanisms of cancer initiation and progression, and finally the clinical implications of this research.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalJournal of Neuro-Oncology
Volume93
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Neoplastic Stem Cells
Brain Neoplasms
Neoplasms
Research
Glioma
Survival

Keywords

  • BTSC
  • Cancer
  • Neuro-oncology
  • Treatment
  • Tumorigenesis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Origins and clinical implications of the brain tumor stem cell hypothesis. / Zaidi, Hasan A.; Kosztowski, Thomas; DiMeco, Francesco; Quiñones-Hinojosa, Alfredo.

In: Journal of Neuro-Oncology, Vol. 93, No. 1, 2009, p. 49-60.

Research output: Contribution to journalArticle

Zaidi, Hasan A. ; Kosztowski, Thomas ; DiMeco, Francesco ; Quiñones-Hinojosa, Alfredo. / Origins and clinical implications of the brain tumor stem cell hypothesis. In: Journal of Neuro-Oncology. 2009 ; Vol. 93, No. 1. pp. 49-60.
@article{125bc7d06ff24466a4ac867394e762ee,
title = "Origins and clinical implications of the brain tumor stem cell hypothesis",
abstract = "With the advent of the cancer stem cell hypothesis, the field of cancer research has experienced a revolution in how we think of and approach cancer. The discovery of {"}brain tumor stem cells{"} has offered an explanation for several long-standing conundrums on why brain tumors behave the way they do to treatment. Despite the great amount of research that has been done in order to understand the molecular aspects of malignant gliomas, the prognosis of brain tumors remains dismal. The slow progress in extending the survival of patients with malignant CNS neoplasms is very likely due to poor understanding of the cell of origin in these tumors. This review article discusses the progress in our understanding of brain tumor stem cells as the cell of origin in brain cancers. We review the different proposed mechanisms of how brain tumor stem cells may originate, the intracellular pathways disrupted in the pathogenesis of BTSCs, the molecular markers used to identify BTSCs, the molecular mechanisms of cancer initiation and progression, and finally the clinical implications of this research.",
keywords = "BTSC, Cancer, Neuro-oncology, Treatment, Tumorigenesis",
author = "Zaidi, {Hasan A.} and Thomas Kosztowski and Francesco DiMeco and Alfredo Qui{\~n}ones-Hinojosa",
year = "2009",
doi = "10.1007/s11060-009-9856-x",
language = "English",
volume = "93",
pages = "49--60",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Springer New York LLC",
number = "1",

}

TY - JOUR

T1 - Origins and clinical implications of the brain tumor stem cell hypothesis

AU - Zaidi, Hasan A.

AU - Kosztowski, Thomas

AU - DiMeco, Francesco

AU - Quiñones-Hinojosa, Alfredo

PY - 2009

Y1 - 2009

N2 - With the advent of the cancer stem cell hypothesis, the field of cancer research has experienced a revolution in how we think of and approach cancer. The discovery of "brain tumor stem cells" has offered an explanation for several long-standing conundrums on why brain tumors behave the way they do to treatment. Despite the great amount of research that has been done in order to understand the molecular aspects of malignant gliomas, the prognosis of brain tumors remains dismal. The slow progress in extending the survival of patients with malignant CNS neoplasms is very likely due to poor understanding of the cell of origin in these tumors. This review article discusses the progress in our understanding of brain tumor stem cells as the cell of origin in brain cancers. We review the different proposed mechanisms of how brain tumor stem cells may originate, the intracellular pathways disrupted in the pathogenesis of BTSCs, the molecular markers used to identify BTSCs, the molecular mechanisms of cancer initiation and progression, and finally the clinical implications of this research.

AB - With the advent of the cancer stem cell hypothesis, the field of cancer research has experienced a revolution in how we think of and approach cancer. The discovery of "brain tumor stem cells" has offered an explanation for several long-standing conundrums on why brain tumors behave the way they do to treatment. Despite the great amount of research that has been done in order to understand the molecular aspects of malignant gliomas, the prognosis of brain tumors remains dismal. The slow progress in extending the survival of patients with malignant CNS neoplasms is very likely due to poor understanding of the cell of origin in these tumors. This review article discusses the progress in our understanding of brain tumor stem cells as the cell of origin in brain cancers. We review the different proposed mechanisms of how brain tumor stem cells may originate, the intracellular pathways disrupted in the pathogenesis of BTSCs, the molecular markers used to identify BTSCs, the molecular mechanisms of cancer initiation and progression, and finally the clinical implications of this research.

KW - BTSC

KW - Cancer

KW - Neuro-oncology

KW - Treatment

KW - Tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=65649138457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649138457&partnerID=8YFLogxK

U2 - 10.1007/s11060-009-9856-x

DO - 10.1007/s11060-009-9856-x

M3 - Article

C2 - 19430882

AN - SCOPUS:65649138457

VL - 93

SP - 49

EP - 60

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

IS - 1

ER -