Orofacial granulomatosis: Clinical signs of different pathologies

Giuseppe Troiano, Mario Dioguardi, Giovanni Giannatempo, Luigi Laino, Nunzio Francesco Testa, Roberto Cocchi, Alfredo De Lillo, Lorenzo Lo Muzio

Research output: Contribution to journalArticlepeer-review


Orofacial granulomatosis (OFG) is an uncommon disease characterized by persistent or recurrent soft tissue enlargement, oral ulceration and a variety of other orofacial features. It could be an oral manifestation of a systemic disease. For a correct differential diagnosis, local and systemic conditions characterized by granulomatous inflammation should be excluded using appropriate clinical and laboratory investigations. In fact, the diagnosis of OFG may be confirmed only by histopathological identification of noncaseating granulomas. The literature from 1943 to 2014 was reviewed with emphasis on the etiology of OFG and on clinical manifestations of systemic pathologies associated with OFG. The precise cause of OFG is still unknown, although several theories have been suggested, such as infection, hereditary factors and allergy. OFG is a disease that has a wide spectrum of presentation, which may include the oral manifestation of a systemic condition such as Crohn's disease, sarcoidosis, granulomatosis with polyangiitis and Melkersson-Rosenthal syndrome.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalMedical Principles and Practice
Issue number2
Publication statusPublished - Dec 25 2015


  • Crohn's disease
  • Granulomatosis with polyangiitis
  • Inflammatory bowel disease
  • Melkersson-Rosenthal syndrome
  • Orofacial granulomatosis
  • Sarcoidosis

ASJC Scopus subject areas

  • Medicine(all)


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