Oropharingeal candidiasis in hiv-infected children: Evaluation of candida SPP multireststent strains presence

D. Caselii, R. Gufminetti, A. Maccabruni, G. Michelone, A. Deicas, L. Artandi

Research output: Contribution to journalArticle

Abstract

Introduction: High incidence of oral Candidas is reported in HIV infected children; although this is not a life-threatening condition, since it may impair nutrition and progress to esophagitis. specific treatment is often requested. Moreover antimicotic resistent strains have been frequently reported in adult patients.To evaluate the incidence of oral thrush and of resistent strains of Candida we studied a group of HIV infected children. Patients: We evaluated 22 HIV infected children (age range 2-12 years), 11 wrth mild disease (l N or B I -2-or CI according to "CDC 95" classification), and 11 with severe disease (IB3- C2or3). Surveillance oral swabs from twenty-two exposed children aged less than one year, who seroreverted in the follow-up, were studied as controls. Oral swabs from children with clinically suspected oral candidiasis. observed over one year, were cufojred. Sensitivity of isolated strains was tested by Kirby-Bauer test Children with confirmed infection were treated with oral fluconazole and then retested on day 21. Muttiresistent strains were those who lacked sensitivity to ≥2 of the eight tested antimicotic drugs. Results: All cultures obtained from children of the control group were negative. Of the 133 cultures from infected children 70 were positive. Candida albicans is the onty isolated species. In the group with mild disease 36/57 cultures were positive (63%), and 19 of these 36 (53%) strains muttiresistent In the group with severe disease 34/76 cuftures were positive (45%) and only 5(15%) were mutoresistent. Conclusions: High incidence of oral trush is confirmed in our children, with a median of 5 infections/child/year. No species other than Candida albicans were found. Mutoresistent Candida strains accounted for 34% (24/70) of all isolates. Surprisinlgy, both occurrence of infection and of multiresistence are more frequent in children without severe immunodeficiency.

Original languageEnglish
Pages (from-to)373-374
Number of pages2
JournalPediatric AIDS and HIV Infection
Volume7
Issue number5
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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