Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus

Sandro Passaretti, Giorgia Mazzoleni, Cristian Vailati, Pier Alberto Testoni

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

AIM To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry (HRM). Patients were divided into two groups on the basis of a normal or pathological pH-metric finding (Ryan Score) and all manometric characteristics of the two groups were compared. RESULTS We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure (median 71 mmHg vs 126 mmHg, p = 0.004) and the median proximal contractile integral (median 215.5 cm· mmHg·s vs 313.5 cm·mmHg·s, p = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mmHg isobaric contour (38.7% vs 15.38%, p < 0.0001). CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.

Original languageEnglish
Pages (from-to)8991-8998
Number of pages8
JournalWorld Journal of Gastroenterology
Volume22
Issue number40
DOIs
Publication statusPublished - Oct 28 2016

Fingerprint

Esophagus
Acids
Manometry
Gastroesophageal Reflux
Upper Esophageal Sphincter
Pharynx
Nose
Ear
Hypersensitivity
Outpatients
Prospective Studies
Pressure
Lung

Keywords

  • Esophagus
  • Gastroesophageal reflux disease
  • High resolution manometry
  • Motility
  • Oropharyngeal reflux
  • PH-metry

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus. / Passaretti, Sandro; Mazzoleni, Giorgia; Vailati, Cristian; Testoni, Pier Alberto.

In: World Journal of Gastroenterology, Vol. 22, No. 40, 28.10.2016, p. 8991-8998.

Research output: Contribution to journalArticle

Passaretti, Sandro ; Mazzoleni, Giorgia ; Vailati, Cristian ; Testoni, Pier Alberto. / Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus. In: World Journal of Gastroenterology. 2016 ; Vol. 22, No. 40. pp. 8991-8998.
@article{0bd17e11a019497282a20eb5195a083f,
title = "Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus",
abstract = "AIM To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry (HRM). Patients were divided into two groups on the basis of a normal or pathological pH-metric finding (Ryan Score) and all manometric characteristics of the two groups were compared. RESULTS We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure (median 71 mmHg vs 126 mmHg, p = 0.004) and the median proximal contractile integral (median 215.5 cm· mmHg·s vs 313.5 cm·mmHg·s, p = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mmHg isobaric contour (38.7{\%} vs 15.38{\%}, p < 0.0001). CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.",
keywords = "Esophagus, Gastroesophageal reflux disease, High resolution manometry, Motility, Oropharyngeal reflux, PH-metry",
author = "Sandro Passaretti and Giorgia Mazzoleni and Cristian Vailati and Testoni, {Pier Alberto}",
year = "2016",
month = "10",
day = "28",
doi = "10.3748/wjg.v22.i40.8991",
language = "English",
volume = "22",
pages = "8991--8998",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "40",

}

TY - JOUR

T1 - Oropharyngeal acid reflux and motility abnormalities of the proximal esophagus

AU - Passaretti, Sandro

AU - Mazzoleni, Giorgia

AU - Vailati, Cristian

AU - Testoni, Pier Alberto

PY - 2016/10/28

Y1 - 2016/10/28

N2 - AIM To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry (HRM). Patients were divided into two groups on the basis of a normal or pathological pH-metric finding (Ryan Score) and all manometric characteristics of the two groups were compared. RESULTS We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure (median 71 mmHg vs 126 mmHg, p = 0.004) and the median proximal contractile integral (median 215.5 cm· mmHg·s vs 313.5 cm·mmHg·s, p = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mmHg isobaric contour (38.7% vs 15.38%, p < 0.0001). CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.

AB - AIM To investigate the relationship between pathological oropharyngeal (OP) acid exposure and esophageal motility in patients with extra-esophageal syndromes. METHODS In this prospective study we enrolled consecutive outpatients with extra-esophageal symptoms suspected to be related to gastroesophageal reflux disease (GERD). We enrolled only patients with a reflux symptom index (RSI) score-higher than 13 and with previous lung, allergy and ear, nose and throat evaluations excluding other specific diagnoses. All patients underwent 24-h OP pH-metry with the Dx probe and esophageal highresolution manometry (HRM). Patients were divided into two groups on the basis of a normal or pathological pH-metric finding (Ryan Score) and all manometric characteristics of the two groups were compared. RESULTS We examined 135 patients with chronic extra-esophageal syndromes. Fifty-one were considered eligible for the study. Of these, 42 decided to participate in the protocol. Patients were divided into two groups on the basis of normal or pathological OP acid exposure. All the HRM parameters were compared for the two groups. Significant differences were found in the median upper esophageal sphincter resting pressure (median 71 mmHg vs 126 mmHg, p = 0.004) and the median proximal contractile integral (median 215.5 cm· mmHg·s vs 313.5 cm·mmHg·s, p = 0.039), both being lower in the group with pathological OP acid exposure, and the number of contractions with small or large breaks, which were more frequent in the same group. This group also had a larger number of peristaltic contractions with breaks in the 20 mmHg isobaric contour (38.7% vs 15.38%, p < 0.0001). CONCLUSION In patients with suspected GERD-related extraesophageal syndromes pathological OP acid exposure was associated with weaker proximal esophageal motility.

KW - Esophagus

KW - Gastroesophageal reflux disease

KW - High resolution manometry

KW - Motility

KW - Oropharyngeal reflux

KW - PH-metry

UR - http://www.scopus.com/inward/record.url?scp=84992752942&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992752942&partnerID=8YFLogxK

U2 - 10.3748/wjg.v22.i40.8991

DO - 10.3748/wjg.v22.i40.8991

M3 - Article

VL - 22

SP - 8991

EP - 8998

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 40

ER -