Orthostatic hypertension: Home blood pressure monitoring for detection and assessment of treatment with doxazosin

Satoshi Hoshide, Gianfranco Parati, Yoshio Matsui, Seiichi Shibazaki, Kazuo Eguchi, Kazuomi Kario

Research output: Contribution to journalArticlepeer-review

Abstract

To determine the role of home blood pressure (BP) monitoring for a reproducible assessment of orthostatic hypertension (OHT) and the effectiveness of hypertension control by doxazosin. In this study, 605 medicated hypertensive outpatients were enrolled. Home BP in the sitting and standing positions was monitored in all patients in the morning and evening for 6 months. According to an open-label multicenter trial design, the patients were randomly allocated to either an intervention group that took doxazosin (1-4 mg) at bedtime or to a control group that did not receive any add-on medication. The patients were divided into deciles of orthostatic BP change as evaluated by home BP monitoring at baseline. Those in the top decile, in the lowest decile and in deciles two through eight were then assigned to the OHT group, the orthostatic hypotension group and the orthostatic normotension group, respectively.Orthostatic BP in the OHYPO group did not change, whereas that of the OHT group was markedly reduced by doxazosin (P

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalHypertension Research
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • doxazosin
  • home blood pressure
  • orthostatic hypertension
  • urinary albumin

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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