TY - JOUR
T1 - Orthostatic intolerance and the postural tachycardia syndrome
T2 - Genetic and environment pathophysiologies
AU - Robertson, David
AU - Shannon, John R.
AU - Biaggioni, Italo
AU - Ertl, Andrew C.
AU - Diedrich, André
AU - Carson, Robert
AU - Furlan, Raffaello
AU - Jacob, Giris
AU - Jordan, Jens
PY - 2001
Y1 - 2001
N2 - Orthostatic intolerance is a common problem for inbound space travelers. There is usually tachycardia on standing but blood pressure may be normal, low or, rarely, elevated. This condition is analogous to the orthostatic intolerance that occurs on Earth in individuals with orthostatic tachycardia, palpitations, mitral valve prolapse, and light-headedness. Our studies during the Neurolab mission indicated that sympathetic nerve traffic is raised in microgravity and that plasma norepinephrine is higher than baseline supine levels but lower than baseline upright levels. A subgroup of patients with familial orthostatic intolerance differ from inbound space travelers in that they have an alanine-to-to-proline mutation at amino acid position 457 in their norepinephrine transporter gene. This leads to poor clearance of norepinephrine from synapses, with consequent raised heart rate. Clinical features of these syndromes are presented.
AB - Orthostatic intolerance is a common problem for inbound space travelers. There is usually tachycardia on standing but blood pressure may be normal, low or, rarely, elevated. This condition is analogous to the orthostatic intolerance that occurs on Earth in individuals with orthostatic tachycardia, palpitations, mitral valve prolapse, and light-headedness. Our studies during the Neurolab mission indicated that sympathetic nerve traffic is raised in microgravity and that plasma norepinephrine is higher than baseline supine levels but lower than baseline upright levels. A subgroup of patients with familial orthostatic intolerance differ from inbound space travelers in that they have an alanine-to-to-proline mutation at amino acid position 457 in their norepinephrine transporter gene. This leads to poor clearance of norepinephrine from synapses, with consequent raised heart rate. Clinical features of these syndromes are presented.
KW - Autonomic
KW - Microgravity
KW - Orthostatic intolerance
KW - Postural tachycardia syndrome
KW - Sympathetic
UR - http://www.scopus.com/inward/record.url?scp=0034968387&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034968387&partnerID=8YFLogxK
M3 - Article
C2 - 11200979
AN - SCOPUS:0034968387
VL - 441
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
SN - 0031-6768
IS - 2-3 SUPPL.
ER -