Orthotopic liver transplantation for alcoholic liver disease: Rates of survival, complications and relapse

Giuseppe Francesco Stefanini, Maurizio Biselli, Gian Luca Grazi, Elio Iovine, Maria Rosaria Moscatello, Lorenzo Marsigli, Francesco Giuseppe Foschi, Fabio Caputo, Alighieri Mazziotti, Mauro Bernardi, Giovanni Gasbarrini, Antonino Cavallari

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background/Aims: Liver transplantation for alcoholic end-stage liver disease remains controversial at many transplant centers. The aim of the present study was to evaluate the outcome of patients with alcoholic liver disease who underwent liver transplantation at Centro Trapianti, Policlinico S. Orsola, Bologna. Methodology: We describe the outcomes of 18 alcoholic patients with end-stage liver disease who received orthotopic liver transplants at our center from April, 1986 to February, 1996. The data obtained was compared with that of 114 patients with virus-related cirrhosis selected as transplant controls. An absolute period of abstinence from alcohol consumption for at least six months was required. Results: Regarding the actuarial survival rate and non-fatal post-transplant complications, no significant differences were noted in comparing the non-alcoholic with the alcoholic recipients, except for a higher incidence of Cytomegalovirus infection in the alcoholic group followed-up for more than four months. The alcoholic relapse rate was 27.2%, but only one patient returned to harmful drinking. Seventy-three percent of subjects who were followed-up for at least six months were occupied in gainful employment. Alcoholic relapse did not affect employment status. Conclusion: This data demonstrates that liver transplantation for selected patients with end-stage alcohol-related cirrhosis achieves good results in survival, complications and employment status, and it appears difficult to defend an inflexible claim to have demonstrated an absolute long-term abstinence before transplantation when a severe deterioration of liver function is present.

Original languageEnglish
Pages (from-to)1356-1359
Number of pages4
JournalHepato-Gastroenterology
Volume44
Issue number17
Publication statusPublished - 1997

Fingerprint

Alcoholic Liver Diseases
Liver Transplantation
Survival Rate
Recurrence
Transplants
End Stage Liver Disease
Fibrosis
Liver
Cytomegalovirus Infections
Alcoholics
Alcohol Drinking
Drinking
Transplantation
Alcohols
Viruses
Survival
Incidence

Keywords

  • Alcohol-related cirrhosis
  • Cytomegalovirus
  • Orthotopic liver transplantation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Stefanini, G. F., Biselli, M., Grazi, G. L., Iovine, E., Moscatello, M. R., Marsigli, L., ... Cavallari, A. (1997). Orthotopic liver transplantation for alcoholic liver disease: Rates of survival, complications and relapse. Hepato-Gastroenterology, 44(17), 1356-1359.

Orthotopic liver transplantation for alcoholic liver disease : Rates of survival, complications and relapse. / Stefanini, Giuseppe Francesco; Biselli, Maurizio; Grazi, Gian Luca; Iovine, Elio; Moscatello, Maria Rosaria; Marsigli, Lorenzo; Foschi, Francesco Giuseppe; Caputo, Fabio; Mazziotti, Alighieri; Bernardi, Mauro; Gasbarrini, Giovanni; Cavallari, Antonino.

In: Hepato-Gastroenterology, Vol. 44, No. 17, 1997, p. 1356-1359.

Research output: Contribution to journalArticle

Stefanini, GF, Biselli, M, Grazi, GL, Iovine, E, Moscatello, MR, Marsigli, L, Foschi, FG, Caputo, F, Mazziotti, A, Bernardi, M, Gasbarrini, G & Cavallari, A 1997, 'Orthotopic liver transplantation for alcoholic liver disease: Rates of survival, complications and relapse', Hepato-Gastroenterology, vol. 44, no. 17, pp. 1356-1359.
Stefanini GF, Biselli M, Grazi GL, Iovine E, Moscatello MR, Marsigli L et al. Orthotopic liver transplantation for alcoholic liver disease: Rates of survival, complications and relapse. Hepato-Gastroenterology. 1997;44(17):1356-1359.
Stefanini, Giuseppe Francesco ; Biselli, Maurizio ; Grazi, Gian Luca ; Iovine, Elio ; Moscatello, Maria Rosaria ; Marsigli, Lorenzo ; Foschi, Francesco Giuseppe ; Caputo, Fabio ; Mazziotti, Alighieri ; Bernardi, Mauro ; Gasbarrini, Giovanni ; Cavallari, Antonino. / Orthotopic liver transplantation for alcoholic liver disease : Rates of survival, complications and relapse. In: Hepato-Gastroenterology. 1997 ; Vol. 44, No. 17. pp. 1356-1359.
@article{cb57756f5b9a4df885ae170dc70dd341,
title = "Orthotopic liver transplantation for alcoholic liver disease: Rates of survival, complications and relapse",
abstract = "Background/Aims: Liver transplantation for alcoholic end-stage liver disease remains controversial at many transplant centers. The aim of the present study was to evaluate the outcome of patients with alcoholic liver disease who underwent liver transplantation at Centro Trapianti, Policlinico S. Orsola, Bologna. Methodology: We describe the outcomes of 18 alcoholic patients with end-stage liver disease who received orthotopic liver transplants at our center from April, 1986 to February, 1996. The data obtained was compared with that of 114 patients with virus-related cirrhosis selected as transplant controls. An absolute period of abstinence from alcohol consumption for at least six months was required. Results: Regarding the actuarial survival rate and non-fatal post-transplant complications, no significant differences were noted in comparing the non-alcoholic with the alcoholic recipients, except for a higher incidence of Cytomegalovirus infection in the alcoholic group followed-up for more than four months. The alcoholic relapse rate was 27.2{\%}, but only one patient returned to harmful drinking. Seventy-three percent of subjects who were followed-up for at least six months were occupied in gainful employment. Alcoholic relapse did not affect employment status. Conclusion: This data demonstrates that liver transplantation for selected patients with end-stage alcohol-related cirrhosis achieves good results in survival, complications and employment status, and it appears difficult to defend an inflexible claim to have demonstrated an absolute long-term abstinence before transplantation when a severe deterioration of liver function is present.",
keywords = "Alcohol-related cirrhosis, Cytomegalovirus, Orthotopic liver transplantation",
author = "Stefanini, {Giuseppe Francesco} and Maurizio Biselli and Grazi, {Gian Luca} and Elio Iovine and Moscatello, {Maria Rosaria} and Lorenzo Marsigli and Foschi, {Francesco Giuseppe} and Fabio Caputo and Alighieri Mazziotti and Mauro Bernardi and Giovanni Gasbarrini and Antonino Cavallari",
year = "1997",
language = "English",
volume = "44",
pages = "1356--1359",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "17",

}

TY - JOUR

T1 - Orthotopic liver transplantation for alcoholic liver disease

T2 - Rates of survival, complications and relapse

AU - Stefanini, Giuseppe Francesco

AU - Biselli, Maurizio

AU - Grazi, Gian Luca

AU - Iovine, Elio

AU - Moscatello, Maria Rosaria

AU - Marsigli, Lorenzo

AU - Foschi, Francesco Giuseppe

AU - Caputo, Fabio

AU - Mazziotti, Alighieri

AU - Bernardi, Mauro

AU - Gasbarrini, Giovanni

AU - Cavallari, Antonino

PY - 1997

Y1 - 1997

N2 - Background/Aims: Liver transplantation for alcoholic end-stage liver disease remains controversial at many transplant centers. The aim of the present study was to evaluate the outcome of patients with alcoholic liver disease who underwent liver transplantation at Centro Trapianti, Policlinico S. Orsola, Bologna. Methodology: We describe the outcomes of 18 alcoholic patients with end-stage liver disease who received orthotopic liver transplants at our center from April, 1986 to February, 1996. The data obtained was compared with that of 114 patients with virus-related cirrhosis selected as transplant controls. An absolute period of abstinence from alcohol consumption for at least six months was required. Results: Regarding the actuarial survival rate and non-fatal post-transplant complications, no significant differences were noted in comparing the non-alcoholic with the alcoholic recipients, except for a higher incidence of Cytomegalovirus infection in the alcoholic group followed-up for more than four months. The alcoholic relapse rate was 27.2%, but only one patient returned to harmful drinking. Seventy-three percent of subjects who were followed-up for at least six months were occupied in gainful employment. Alcoholic relapse did not affect employment status. Conclusion: This data demonstrates that liver transplantation for selected patients with end-stage alcohol-related cirrhosis achieves good results in survival, complications and employment status, and it appears difficult to defend an inflexible claim to have demonstrated an absolute long-term abstinence before transplantation when a severe deterioration of liver function is present.

AB - Background/Aims: Liver transplantation for alcoholic end-stage liver disease remains controversial at many transplant centers. The aim of the present study was to evaluate the outcome of patients with alcoholic liver disease who underwent liver transplantation at Centro Trapianti, Policlinico S. Orsola, Bologna. Methodology: We describe the outcomes of 18 alcoholic patients with end-stage liver disease who received orthotopic liver transplants at our center from April, 1986 to February, 1996. The data obtained was compared with that of 114 patients with virus-related cirrhosis selected as transplant controls. An absolute period of abstinence from alcohol consumption for at least six months was required. Results: Regarding the actuarial survival rate and non-fatal post-transplant complications, no significant differences were noted in comparing the non-alcoholic with the alcoholic recipients, except for a higher incidence of Cytomegalovirus infection in the alcoholic group followed-up for more than four months. The alcoholic relapse rate was 27.2%, but only one patient returned to harmful drinking. Seventy-three percent of subjects who were followed-up for at least six months were occupied in gainful employment. Alcoholic relapse did not affect employment status. Conclusion: This data demonstrates that liver transplantation for selected patients with end-stage alcohol-related cirrhosis achieves good results in survival, complications and employment status, and it appears difficult to defend an inflexible claim to have demonstrated an absolute long-term abstinence before transplantation when a severe deterioration of liver function is present.

KW - Alcohol-related cirrhosis

KW - Cytomegalovirus

KW - Orthotopic liver transplantation

UR - http://www.scopus.com/inward/record.url?scp=9844237020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9844237020&partnerID=8YFLogxK

M3 - Article

C2 - 9356855

AN - SCOPUS:9844237020

VL - 44

SP - 1356

EP - 1359

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 17

ER -