Orthotopic liver transplantation for Byler's disease

E. Torri, A. Lucianetti, D. Pinelli, V. Corno, M. Guizzetti, G. Maldini, M. Zambelli, A. Bertani, M. L. Melzi, D. Alberti, E. Doffria, M. Giovanelli, G. Torre, M. Spada, B. Gridelli, M. Colledan

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Abstract

In this study we analyzed the features of 12 patients who underwent liver transplantation for progressive familial intrahepatic cholestasis (Byler's disease [BD]) in view of the technical features of the OLTx, incidence and type of complications, need for retransplantation, as well as patient and graft survivals. BD was the indication in 12 patients of median age 1.32 years and median weight 10 kg. Median follow-up was 670 days. Major surgical complications requiring reintervention occurred in three patients. No thrombosis of the hepatic artery was observed. Infections with positive blood cultures were diagnosed in four patients. One patient had a biliary anastomotic stenosis successfully treated by percutaneous techniques. Four patients had episodes of acute rejection treated with steroids. Two patients were retransplanted, both of whom died in the early postoperative period due to hepatic vein thrombosis and venoenteric fistula. The actuarial patient and graft survival was 83% at 1 year and 83% at 5 years. Split-liver grafts represent an excellent organ supply for these patients, achieving good results with no mortality on the waiting list.

Original languageEnglish
Pages (from-to)1149-1150
Number of pages2
JournalTransplantation Proceedings
Volume37
Issue number2
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Liver Transplantation
Graft Survival
Progressive familial intrahepatic 1 Cholestasis
Budd-Chiari Syndrome
Waiting Lists
Hepatic Artery
Postoperative Period
Fistula
Pathologic Constriction
Thrombosis
Steroids
Transplants
Weights and Measures
Mortality
Liver
Incidence
Infection

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Torri, E., Lucianetti, A., Pinelli, D., Corno, V., Guizzetti, M., Maldini, G., ... Colledan, M. (2005). Orthotopic liver transplantation for Byler's disease. Transplantation Proceedings, 37(2), 1149-1150. https://doi.org/10.1016/j.transproceed.2005.01.041

Orthotopic liver transplantation for Byler's disease. / Torri, E.; Lucianetti, A.; Pinelli, D.; Corno, V.; Guizzetti, M.; Maldini, G.; Zambelli, M.; Bertani, A.; Melzi, M. L.; Alberti, D.; Doffria, E.; Giovanelli, M.; Torre, G.; Spada, M.; Gridelli, B.; Colledan, M.

In: Transplantation Proceedings, Vol. 37, No. 2, 03.2005, p. 1149-1150.

Research output: Contribution to journalArticle

Torri, E, Lucianetti, A, Pinelli, D, Corno, V, Guizzetti, M, Maldini, G, Zambelli, M, Bertani, A, Melzi, ML, Alberti, D, Doffria, E, Giovanelli, M, Torre, G, Spada, M, Gridelli, B & Colledan, M 2005, 'Orthotopic liver transplantation for Byler's disease', Transplantation Proceedings, vol. 37, no. 2, pp. 1149-1150. https://doi.org/10.1016/j.transproceed.2005.01.041
Torri E, Lucianetti A, Pinelli D, Corno V, Guizzetti M, Maldini G et al. Orthotopic liver transplantation for Byler's disease. Transplantation Proceedings. 2005 Mar;37(2):1149-1150. https://doi.org/10.1016/j.transproceed.2005.01.041
Torri, E. ; Lucianetti, A. ; Pinelli, D. ; Corno, V. ; Guizzetti, M. ; Maldini, G. ; Zambelli, M. ; Bertani, A. ; Melzi, M. L. ; Alberti, D. ; Doffria, E. ; Giovanelli, M. ; Torre, G. ; Spada, M. ; Gridelli, B. ; Colledan, M. / Orthotopic liver transplantation for Byler's disease. In: Transplantation Proceedings. 2005 ; Vol. 37, No. 2. pp. 1149-1150.
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