Orthotopic liver xenotransplantation in the baboon

B. Gridelli, S. Gatti, A. Piazzini, M. E. Donato, J. Stark, W. Deklerk, M. Langer, P. Reggiani, P. Andreani, S. Cristina, L. R. Fassati, D. Galmarini

Research output: Contribution to journalArticle

Abstract

Liver xenotransplantation could overcome the dramatic shortage of cadaveric organs and prevent the reinfection of human liver grafts by B and C hepatitis viruses. In an experimental model of Vervet monkey to Chacma baboon liver xenotransplantation the characteristics of hepatic xenograft rejection and some elementary synthetic functions of the liver in the xenogeneic environment were studied. Extended survival after xenotransplantation was obtained with a cyclosporine-based immunosuppressive protocol. No major differences in the histology and immunopathology of allografts and xenografts were noted suggesting that the same immunologic mechanisms were operative. Liver xenografts supported the life of recipient baboons for over one year without overt metabolic defects.

Original languageEnglish
Pages (from-to)148-150
Number of pages3
JournalTransplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft
Volume6
Issue number2
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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    Gridelli, B., Gatti, S., Piazzini, A., Donato, M. E., Stark, J., Deklerk, W., Langer, M., Reggiani, P., Andreani, P., Cristina, S., Fassati, L. R., & Galmarini, D. (1994). Orthotopic liver xenotransplantation in the baboon. Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft, 6(2), 148-150.