Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules

Riccardo Pampena, Tamara Palmieri, Athanassios Kyrgidis, Dafne Ramundo, Cinzia Iotti, Aimilios Lallas, Elvira Moscarella, Stefania Borsari, Giuseppe Argenziano, Caterina Longo

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Radiotherapy is an established treatment for some types of patients with nonmelanoma skin cancer. A hypofractionated schedule has been proposed as a valuable option for elderly disabled patients to minimize the number of hospital visits.

OBJECTIVE: We sought to compare a weekly hypofractionated orthovoltage radiotherapy regimen with a standard daily one for the treatment of nonmelanoma skin cancer.

METHODS: A retrospective cohort study was performed on 436 tumors. Overall survival, disease-free survival, and cosmetic outcome were measured. Life-table analysis, Kaplan-Meier survival analysis, and multivariate Cox regression model were performed.

RESULTS: The hypofractionated regimen was not associated with increased recurrence rates and mortality, or with a poorer cosmetic outcome, when compared with the daily schedule.

LIMITATIONS: Absence of complete information about acute treatment toxicity and a shorter follow-up time for patients receiving the weekly schedule are limitations of this study.

CONCLUSIONS: A weekly hypofractionated regimen of orthovoltage radiotherapy seems to be the most appropriate approach in elderly disabled patients with nonmelanoma skin cancers.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number2
Publication statusPublished - Feb 1 2016


  • basal cell carcinoma
  • keratinocyte carcinoma
  • radiotherapy
  • skin cancer
  • squamous cell carcinoma
  • therapy

ASJC Scopus subject areas

  • Medicine(all)


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