Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules

Riccardo Pampena, Tamara Palmieri, Athanassios Kyrgidis, Dafne Ramundo, Cinzia Iotti, Aimilios Lallas, Elvira Moscarella, Stefania Borsari, Giuseppe Argenziano, Caterina Longo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

BACKGROUND: Radiotherapy is an established treatment for some types of patients with nonmelanoma skin cancer. A hypofractionated schedule has been proposed as a valuable option for elderly disabled patients to minimize the number of hospital visits.

OBJECTIVE: We sought to compare a weekly hypofractionated orthovoltage radiotherapy regimen with a standard daily one for the treatment of nonmelanoma skin cancer.

METHODS: A retrospective cohort study was performed on 436 tumors. Overall survival, disease-free survival, and cosmetic outcome were measured. Life-table analysis, Kaplan-Meier survival analysis, and multivariate Cox regression model were performed.

RESULTS: The hypofractionated regimen was not associated with increased recurrence rates and mortality, or with a poorer cosmetic outcome, when compared with the daily schedule.

LIMITATIONS: Absence of complete information about acute treatment toxicity and a shorter follow-up time for patients receiving the weekly schedule are limitations of this study.

CONCLUSIONS: A weekly hypofractionated regimen of orthovoltage radiotherapy seems to be the most appropriate approach in elderly disabled patients with nonmelanoma skin cancers.

Original languageEnglish
Pages (from-to)341-347
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume74
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Skin Neoplasms
Appointments and Schedules
Radiotherapy
Cosmetics
Life Tables
Kaplan-Meier Estimate
Survival Analysis
Proportional Hazards Models
Disease-Free Survival
Cohort Studies
Therapeutics
Retrospective Studies
Recurrence
Survival
Mortality
Neoplasms

Keywords

  • basal cell carcinoma
  • keratinocyte carcinoma
  • radiotherapy
  • skin cancer
  • squamous cell carcinoma
  • therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC) : Comparison between 2 different schedules. / Pampena, Riccardo; Palmieri, Tamara; Kyrgidis, Athanassios; Ramundo, Dafne; Iotti, Cinzia; Lallas, Aimilios; Moscarella, Elvira; Borsari, Stefania; Argenziano, Giuseppe; Longo, Caterina.

In: Journal of the American Academy of Dermatology, Vol. 74, No. 2, 01.02.2016, p. 341-347.

Research output: Contribution to journalArticle

Pampena, R, Palmieri, T, Kyrgidis, A, Ramundo, D, Iotti, C, Lallas, A, Moscarella, E, Borsari, S, Argenziano, G & Longo, C 2016, 'Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules', Journal of the American Academy of Dermatology, vol. 74, no. 2, pp. 341-347. https://doi.org/10.1016/j.jaad.2015.09.031
Pampena, Riccardo ; Palmieri, Tamara ; Kyrgidis, Athanassios ; Ramundo, Dafne ; Iotti, Cinzia ; Lallas, Aimilios ; Moscarella, Elvira ; Borsari, Stefania ; Argenziano, Giuseppe ; Longo, Caterina. / Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC) : Comparison between 2 different schedules. In: Journal of the American Academy of Dermatology. 2016 ; Vol. 74, No. 2. pp. 341-347.
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