TY - JOUR
T1 - Oscillations of cytosolic calcium in rat chromaffin cells
T2 - Dual modulation in frequency and amplitude
AU - D'Andrea, P.
AU - Codazzi, F.
AU - Zacchetti, D.
AU - Meldolesi, J.
AU - Grohovaz, F.
PY - 1994
Y1 - 1994
N2 - Rat chromaffin cells in primary culture have a high tendency to exhibit [Ca2+](i) oscillations, spontaneously or alter moderate stimulation with treatments that induce polyphosphoinositide hydrolysis or mild depolarization. Previous studies in a variety of cell systems had shown that strengthening of the above treatments increases the frequency and not the amplitude of the oscillations. We now demonstrate that in cultured chromaffin cells either one of these oscillation reinforcements can be elicited, depending on whether the Ca2+ influx induced by the applied stimulus is asynchronous with or timed by the [Ca2+](i) spikes of the oscillations. In excitable cells the encoding of the oscillation activity appears therefore to operate according to not only digital (modulation in frequency) but also analog (modulation in amplitude) models.
AB - Rat chromaffin cells in primary culture have a high tendency to exhibit [Ca2+](i) oscillations, spontaneously or alter moderate stimulation with treatments that induce polyphosphoinositide hydrolysis or mild depolarization. Previous studies in a variety of cell systems had shown that strengthening of the above treatments increases the frequency and not the amplitude of the oscillations. We now demonstrate that in cultured chromaffin cells either one of these oscillation reinforcements can be elicited, depending on whether the Ca2+ influx induced by the applied stimulus is asynchronous with or timed by the [Ca2+](i) spikes of the oscillations. In excitable cells the encoding of the oscillation activity appears therefore to operate according to not only digital (modulation in frequency) but also analog (modulation in amplitude) models.
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U2 - 10.1006/bbrc.1994.2801
DO - 10.1006/bbrc.1994.2801
M3 - Article
C2 - 7528499
AN - SCOPUS:0028618302
VL - 205
SP - 1264
EP - 1269
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -