Oscillatory MEG response to human locomotion is modulated by periventricular lesions

Marina Pavlova, Werner Lutzenberger, Alexander N. Sokolov, Niels Birbaumer, Ingeborg Krägeloh-Mann

Research output: Contribution to journalArticlepeer-review

Abstract

Veridical processing of biological movement is of immense value for adaptive behavior and social communication. Here we ask whether and, if so, how oscillatory cortical magnetoencephalographic (MEG) response to biological motion is modulated by early damage to periventricular regions that might affect the pathways interconnecting subcortical structures with cortex and cortico-cortical connectivity. The visual sensitivity to biological motion was lower in adolescents with periventricular leukomalacia (PVL). In controls, the evoked oscillatory MEG response (26.5 Hz) to biological motion peaked at a latency of 170 ms over the right temporo-parietal cortex. This increase was absent in PVL patients. By contrast, peaks in the oscillatory response to biological motion of lower frequency (23.5 Hz) were found in PVL patients later, at a latency of 290 ms over the left temporal region. The findings provide the first evidence for modulation of oscillatory cortical activity by periventricular lesions. The data suggest that PVL affects the brain connectivity with the right temporo-parietal cortex leading to disintegration of the neural network engaged in biological motion processing.

Original languageEnglish
Pages (from-to)1256-1263
Number of pages8
JournalNeuroImage
Volume35
Issue number3
DOIs
Publication statusPublished - Apr 15 2007

Keywords

  • Biological motion processing
  • MEG
  • Oscillatory brain activity
  • Periventricular lesions
  • Right temporal cortex
  • Visual psychophysics

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

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