Osmolar changes and neural activity in frog vestibular organs

G. Zucca, A. Maracci, V. Milesi, M. Trimarchi, E. Mira, M. Manfrin, S. Quaglieri, P. Valli

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalActa Oto-Laryngologica
Volume115
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Hypertonic Solutions
Hypotonic Solutions
Anura
Urea
Mannitol
Inner Ear
Glycerol
Sucrose
Reference Values
Glucose

Keywords

  • Endolymphatic hydrops
  • Meniere's disease
  • Osmolar effects
  • Vestibular organs

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Zucca, G., Maracci, A., Milesi, V., Trimarchi, M., Mira, E., Manfrin, M., ... Valli, P. (1995). Osmolar changes and neural activity in frog vestibular organs. Acta Oto-Laryngologica, 115(1), 34-39. https://doi.org/10.3109/00016489509133343

Osmolar changes and neural activity in frog vestibular organs. / Zucca, G.; Maracci, A.; Milesi, V.; Trimarchi, M.; Mira, E.; Manfrin, M.; Quaglieri, S.; Valli, P.

In: Acta Oto-Laryngologica, Vol. 115, No. 1, 1995, p. 34-39.

Research output: Contribution to journalArticle

Zucca, G, Maracci, A, Milesi, V, Trimarchi, M, Mira, E, Manfrin, M, Quaglieri, S & Valli, P 1995, 'Osmolar changes and neural activity in frog vestibular organs', Acta Oto-Laryngologica, vol. 115, no. 1, pp. 34-39. https://doi.org/10.3109/00016489509133343
Zucca, G. ; Maracci, A. ; Milesi, V. ; Trimarchi, M. ; Mira, E. ; Manfrin, M. ; Quaglieri, S. ; Valli, P. / Osmolar changes and neural activity in frog vestibular organs. In: Acta Oto-Laryngologica. 1995 ; Vol. 115, No. 1. pp. 34-39.
@article{1a595c2fcbf04bd19be462fae4aa838a,
title = "Osmolar changes and neural activity in frog vestibular organs",
abstract = "The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.",
keywords = "Endolymphatic hydrops, Meniere's disease, Osmolar effects, Vestibular organs",
author = "G. Zucca and A. Maracci and V. Milesi and M. Trimarchi and E. Mira and M. Manfrin and S. Quaglieri and P. Valli",
year = "1995",
doi = "10.3109/00016489509133343",
language = "English",
volume = "115",
pages = "34--39",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Osmolar changes and neural activity in frog vestibular organs

AU - Zucca, G.

AU - Maracci, A.

AU - Milesi, V.

AU - Trimarchi, M.

AU - Mira, E.

AU - Manfrin, M.

AU - Quaglieri, S.

AU - Valli, P.

PY - 1995

Y1 - 1995

N2 - The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.

AB - The effects of hypotonic and hypertonic solutions (the normal value was 240 mOsm) on posterior canal resting and evoked discharge were studied in isolated labyrinth preparations. Hypotonic solutions (60 180 mOsm) were obtained by reducing the perilymphatic NaCl content. Hypertonic solutions (300 420 mOsm) were obtained by adding to normal perilymphatic solutions suitable amounts of NaCl. glucose, sucrose, glycerol, mannitol and urea. The results demonstrated that any kind of receptor activity was inhibited by hypotonic solutions. On the contrary, hypertonic solutions produced different effects on resting and evoked activity. The resting discharge was, with the exception of urea, constantly increased whereas the evoked responses were constantly decreased by all the hypertonic solutions tested. The possible effects of media with changed osinolarily in Meniere's patients is also discussed.

KW - Endolymphatic hydrops

KW - Meniere's disease

KW - Osmolar effects

KW - Vestibular organs

UR - http://www.scopus.com/inward/record.url?scp=0028868123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028868123&partnerID=8YFLogxK

U2 - 10.3109/00016489509133343

DO - 10.3109/00016489509133343

M3 - Article

C2 - 7762382

AN - SCOPUS:0028868123

VL - 115

SP - 34

EP - 39

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 1

ER -