Osmophobia in allodynic migraineurs: cause or consequence of central sensitization?

C. Lovati, L. Giani, D. Castoldi, C. Mariotti D’Alessandro, F. DeAngeli, E. Capiluppi, D. D’Amico, C. Mariani

Research output: Contribution to journalArticle

Abstract

Migraine is a primary headache characterized by recurrent attacks of head pain associated with nausea or vomit, photophobia, phonophobia and osmophobia. The presence of osmophobia during migraine attacks seems to be a very specific complaint. Cutaneous allodynia (CA) is very common in migraineurs, and it is the most evident clinical manifestation of central sensitization, a mechanism involved in migraine chronification. This study was aimed at identifying the possible correlation between osmophobia and CA in migraineurs. 673 migraineurs were studied (492 episodic, 181 chronic). The prevalence of both CA and osmophobia was higher in chronic than in episodic migraineurs. The association between these two symptoms was significant in chronic migraineurs at Chi square test. The highlighted relationship between CA and osmophobia may be interpreted in different ways: central sensitization induced by recurrent pain stimulation may in parallel induce a distortion of both cutaneous sensitivity (CA) and olfaction (osmophobia); alternatively, the recurrent olfactory stimulation in subjects with a hypersensitivity to olfactory stimuli may co-work with repetitive pain stimulation to induce the central sensitization process.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalNeurological Sciences
Volume36
DOIs
Publication statusPublished - May 30 2015

Fingerprint

Central Nervous System Sensitization
Hyperalgesia
Skin
Migraine Disorders
Headache
Hyperacusis
Pain
Photophobia
Smell
Chi-Square Distribution
Nausea
Hypersensitivity

Keywords

  • Chronic migraine
  • Cutaneous allodynia
  • Migraine
  • Osmophobia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

Cite this

Lovati, C., Giani, L., Castoldi, D., Mariotti D’Alessandro, C., DeAngeli, F., Capiluppi, E., ... Mariani, C. (2015). Osmophobia in allodynic migraineurs: cause or consequence of central sensitization? Neurological Sciences, 36, 145-147. https://doi.org/10.1007/s10072-015-2141-1

Osmophobia in allodynic migraineurs : cause or consequence of central sensitization? / Lovati, C.; Giani, L.; Castoldi, D.; Mariotti D’Alessandro, C.; DeAngeli, F.; Capiluppi, E.; D’Amico, D.; Mariani, C.

In: Neurological Sciences, Vol. 36, 30.05.2015, p. 145-147.

Research output: Contribution to journalArticle

Lovati, C, Giani, L, Castoldi, D, Mariotti D’Alessandro, C, DeAngeli, F, Capiluppi, E, D’Amico, D & Mariani, C 2015, 'Osmophobia in allodynic migraineurs: cause or consequence of central sensitization?', Neurological Sciences, vol. 36, pp. 145-147. https://doi.org/10.1007/s10072-015-2141-1
Lovati C, Giani L, Castoldi D, Mariotti D’Alessandro C, DeAngeli F, Capiluppi E et al. Osmophobia in allodynic migraineurs: cause or consequence of central sensitization? Neurological Sciences. 2015 May 30;36:145-147. https://doi.org/10.1007/s10072-015-2141-1
Lovati, C. ; Giani, L. ; Castoldi, D. ; Mariotti D’Alessandro, C. ; DeAngeli, F. ; Capiluppi, E. ; D’Amico, D. ; Mariani, C. / Osmophobia in allodynic migraineurs : cause or consequence of central sensitization?. In: Neurological Sciences. 2015 ; Vol. 36. pp. 145-147.
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