Osmophobia in migraine classification: A multicentre study in juvenile patients

D. De Carlo; L. Dal Zotto; E. Perissinotto; L. Gallo; M. Gatta; U. Balottin; G. Mazzotta; D. Moscato; V. Raieli; L. N. Rossi; R. Sangermani; S. Soriani; C. Termine; E. Tozzi; A. Vecchio; G. Zanchin; P. A. Battistella

doi:10.1177/0333102410362928

Osmophobia in migraine classification: A multicentre study in juvenile patients

D. De Carlo, L. Dal Zotto, E. Perissinotto, L. Gallo, M. Gatta, U. Balottin, G. Mazzotta, D. Moscato, V. Raieli, L. N. Rossi, R. Sangermani, S. Soriani, C. Termine, E. Tozzi, A. Vecchio, G. Zanchin, P. A. Battistella

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Aims: This study was planned to investigate the diagnostic utility of osmophobia as criterion for migraine without aura (MO) as proposed in the Appendix (A1.1) of the International Classification of Headache Disorders (ICHD-II, 2004). Methods: We analysed 1020 patients presenting at 10 Italian juvenile headache centres, 622 affected by migraine (M) and 328 by tension-type headache (TTH); 70 were affected by headache not elsewhere classified (NEC) in ICHD-II. By using a semi-structured questionnaire, the prevalence of osmophobia was 26.9%, significantly higher in M than TTH patients (34.6% vs 14.3%). Results: Osmophobia was correlated with: (i) family history of M and osmophobia; and (ii) other accompanying symptoms of M. By applying these 'new' criteria, we found an agreement with the current criteria for the diagnosis of migraine without aura (MO) in 96.2% of cases; 54.3% of previously unclassifiable patients received a 'new' diagnosis. Conclusions: In conclusion, this study demonstrates that this new approach, proposed in the Appendix (A1.1), appears easy to apply and should improve the diagnostic standard of ICHD-II in young patients too.

Original language	English
Pages (from-to)	1486-1494
Number of pages	9
Journal	Cephalalgia
Volume	30
Issue number	12
DOIs	https://doi.org/10.1177/0333102410362928
Publication status	Published - Dec 2010

Keywords

International Classification of Headache Disorder 2nd edn
Juvenile primary headache
Migraine without aura
Osmophobia
Tension-type headache

ASJC Scopus subject areas

Clinical Neurology
Medicine(all)

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De Carlo, D., Dal Zotto, L., Perissinotto, E., Gallo, L., Gatta, M., Balottin, U., Mazzotta, G., Moscato, D., Raieli, V., Rossi, L. N., Sangermani, R., Soriani, S., Termine, C., Tozzi, E., Vecchio, A., Zanchin, G., & Battistella, P. A. (2010). Osmophobia in migraine classification: A multicentre study in juvenile patients. Cephalalgia, 30(12), 1486-1494. https://doi.org/10.1177/0333102410362928

Osmophobia in migraine classification : A multicentre study in juvenile patients. / De Carlo, D.; Dal Zotto, L.; Perissinotto, E.; Gallo, L.; Gatta, M.; Balottin, U.; Mazzotta, G.; Moscato, D.; Raieli, V.; Rossi, L. N.; Sangermani, R.; Soriani, S.; Termine, C.; Tozzi, E.; Vecchio, A.; Zanchin, G.; Battistella, P. A.

In: Cephalalgia, Vol. 30, No. 12, 12.2010, p. 1486-1494.

Research output: Contribution to journal › Article › peer-review

De Carlo, D, Dal Zotto, L, Perissinotto, E, Gallo, L, Gatta, M, Balottin, U, Mazzotta, G, Moscato, D, Raieli, V, Rossi, LN, Sangermani, R, Soriani, S, Termine, C, Tozzi, E, Vecchio, A, Zanchin, G & Battistella, PA 2010, 'Osmophobia in migraine classification: A multicentre study in juvenile patients', Cephalalgia, vol. 30, no. 12, pp. 1486-1494. https://doi.org/10.1177/0333102410362928

De Carlo, D. ; Dal Zotto, L. ; Perissinotto, E. ; Gallo, L. ; Gatta, M. ; Balottin, U. ; Mazzotta, G. ; Moscato, D. ; Raieli, V. ; Rossi, L. N. ; Sangermani, R. ; Soriani, S. ; Termine, C. ; Tozzi, E. ; Vecchio, A. ; Zanchin, G. ; Battistella, P. A. / Osmophobia in migraine classification : A multicentre study in juvenile patients. In: Cephalalgia. 2010 ; Vol. 30, No. 12. pp. 1486-1494.

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abstract = "Aims: This study was planned to investigate the diagnostic utility of osmophobia as criterion for migraine without aura (MO) as proposed in the Appendix (A1.1) of the International Classification of Headache Disorders (ICHD-II, 2004). Methods: We analysed 1020 patients presenting at 10 Italian juvenile headache centres, 622 affected by migraine (M) and 328 by tension-type headache (TTH); 70 were affected by headache not elsewhere classified (NEC) in ICHD-II. By using a semi-structured questionnaire, the prevalence of osmophobia was 26.9%, significantly higher in M than TTH patients (34.6% vs 14.3%). Results: Osmophobia was correlated with: (i) family history of M and osmophobia; and (ii) other accompanying symptoms of M. By applying these 'new' criteria, we found an agreement with the current criteria for the diagnosis of migraine without aura (MO) in 96.2% of cases; 54.3% of previously unclassifiable patients received a 'new' diagnosis. Conclusions: In conclusion, this study demonstrates that this new approach, proposed in the Appendix (A1.1), appears easy to apply and should improve the diagnostic standard of ICHD-II in young patients too.",

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AU - Dal Zotto, L.

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AU - Gatta, M.

AU - Balottin, U.

AU - Mazzotta, G.

AU - Moscato, D.

AU - Raieli, V.

AU - Rossi, L. N.

AU - Sangermani, R.

AU - Soriani, S.

AU - Termine, C.

AU - Tozzi, E.

AU - Vecchio, A.

AU - Zanchin, G.

AU - Battistella, P. A.

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