Abstract
Hypertonic saline (100 mmol in 50 ml) was injected intravenously over 5 min in two groups of moderate essential hypertensive patients (group 1, n = 13; group 2, n = 6). In group 2, arterial pressure had been lowered by infusion of clonidine (0.3mg in 100ml saline), from 186 ±8/116 ±3 to 146 ± 9/98 ±5 mmHg (mean ± s.e.m.). The hypertonic stimulus increased the plasma osmolality of all subjects from 288 ± 1 to 296 ± 1 mosmol/kg (P <0.01). Plasma vasopressin increased from baseline values that were not significantly different (P
| Original language | English |
|---|---|
| Pages (from-to) | S200-S201 |
| Journal | Journal of Hypertension, Supplement |
| Volume | 7 |
| Publication status | Published - 1989 |
Keywords
- Clonidine
- Osmoregulation
- Vasopressin
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
- Internal Medicine
- Endocrinology
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Del Bo, A., Marabini, M., Aghemo, A., & Zanchetti, A. (1989). Osmoregulation of vasopressin during acute lowering of arterial pressure by clonidine in moderate hypertension. Journal of Hypertension, Supplement, 7, S200-S201.