TY - JOUR
T1 - Osseointegration of Titanium Implants with Different Rough Surfaces
T2 - A Histologic and Histomorphometric Study in an Adult Minipig Model
AU - Fabbro, Massimo Del
AU - Taschieri, Silvio
AU - Canciani, Elena
AU - Addis, Alessandro
AU - Musto, Federica
AU - Weinstein, Roberto
AU - Dellavia, Claudia
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Background: Many chemical and physical modifications of titanium surfaces were introduced, aiming at improving surface bioactivity, but few comparative evidence exists. Objective: To evaluate histologically in minipigs the osseointegration of implants made of commercially pure (CP) titanium or titanium alloy, treated by different roughening procedures. Material and Methods: Three sandblasted acid-etched (SA) surfaces, 2 anodized (AN), and 1 double acid-etched (DAE) were compared. Surface microtopography was characterized with scanning electron microscope; surface element composition was also assessed. One implant per group was inserted in each proximal tibia of 2 minipigs. Three months after healing, block biopsies were taken for histomorphometric analysis. Implant stability quotient (ISQ) was measured at insertion and before harvesting. Results: The highest amount of cortical bone-implant contact was observed around SA implants and showed positive correlation with surface roughness. The greatest increase in ISQ was observed in CP-AN implants. In the medullary region, SA implants showed the best osteogenic response, whereas inflammatory cells were found around DAE and alloy-AN implants. Conclusions: SA surfaces were more osteogenic than anodized or dual acid-etched ones, although not significantly. Surface roughness affected osseointegration.
AB - Background: Many chemical and physical modifications of titanium surfaces were introduced, aiming at improving surface bioactivity, but few comparative evidence exists. Objective: To evaluate histologically in minipigs the osseointegration of implants made of commercially pure (CP) titanium or titanium alloy, treated by different roughening procedures. Material and Methods: Three sandblasted acid-etched (SA) surfaces, 2 anodized (AN), and 1 double acid-etched (DAE) were compared. Surface microtopography was characterized with scanning electron microscope; surface element composition was also assessed. One implant per group was inserted in each proximal tibia of 2 minipigs. Three months after healing, block biopsies were taken for histomorphometric analysis. Implant stability quotient (ISQ) was measured at insertion and before harvesting. Results: The highest amount of cortical bone-implant contact was observed around SA implants and showed positive correlation with surface roughness. The greatest increase in ISQ was observed in CP-AN implants. In the medullary region, SA implants showed the best osteogenic response, whereas inflammatory cells were found around DAE and alloy-AN implants. Conclusions: SA surfaces were more osteogenic than anodized or dual acid-etched ones, although not significantly. Surface roughness affected osseointegration.
KW - bone healing
KW - dental implants
KW - implant surface
KW - Key Words: Animal model
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U2 - 10.1097/ID.0000000000000560
DO - 10.1097/ID.0000000000000560
M3 - Article
AN - SCOPUS:85013812257
VL - 26
SP - 357
EP - 366
JO - The International journal of oral implantology : implantologist
JF - The International journal of oral implantology : implantologist
SN - 1056-6163
IS - 3
ER -