Osseous lesions in chronic phlebolymphedema: Pathological pattern identification in modern man and in ancient human remains

E. Fulcheri, S. Boccone, F. Boccardo, S. Valdevit, C. Campisi

Research output: Contribution to journalArticle

Abstract

Paleopathology is by now a well established discipline with regard to applied methodology and systematic classification of acquired scientific information. Only by integrating modern medicine with the medicine of human beings of the past can both disciplines draw fruitful and bilateral knowledge contributions. This work aims to demonstrate that paleopathological research of ancient human remains can provide very interesting information to clinical studies and investigations as concerns the pathology of chronic lymphedema. Many aspects involving Lymphology and Phlebology are often tackled in daily clinical practice. The close correlation between lymphatic system and venous circulation begins as early as during embryo development. When, during inflammation processes, lymphothrombosis or prolonged lymphangiospasm prevent lymphatics from properly draining into the interstitial space, perivenous lymphangitis is likely to develop affecting vasa lymphatica vasorum. When these conditions persist, tissues begin to become fibrotic, with subsequent increase in wall thickness and stiffness of deep, communicating, and superficial vein branches. All these conditions together can, in turn, stimulate a subperiosteal bone reaction in those areas where the vessel runs close to the periosteum, with no muscle or fibrous fascial tissue in between. Bone imprints are thus formed, as if a mould were taken of vascular structures. Through a retrospective study of current patients with phlebolymphedema, axial tomography scans could be assessed again, thus proving the presence of similar lesions. Bone imprints of vascular origin have thus always proved to be associated with chronic vessel inflammation and to be a consequence of this condition.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalEuropean Journal of Lymphology and Related Problems
Volume16
Issue number47
Publication statusPublished - 2006

Fingerprint

Bone and Bones
Blood Vessels
Paleopathology
Lymphangitis
Vasa Vasorum
Inflammation
Lymphatic System
Periosteum
Modern 1601-history
Lymphedema
Embryonic Development
Veins
Fungi
Retrospective Studies
Tomography
Medicine
Pathology
Muscles
Research
Body Remains

Keywords

  • Paleopathology
  • Periostitis
  • Phlebolymphedema
  • Vascular lesions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Osseous lesions in chronic phlebolymphedema : Pathological pattern identification in modern man and in ancient human remains. / Fulcheri, E.; Boccone, S.; Boccardo, F.; Valdevit, S.; Campisi, C.

In: European Journal of Lymphology and Related Problems, Vol. 16, No. 47, 2006, p. 21-28.

Research output: Contribution to journalArticle

@article{18a429b6fbff4b6c8f3db7596edb3826,
title = "Osseous lesions in chronic phlebolymphedema: Pathological pattern identification in modern man and in ancient human remains",
abstract = "Paleopathology is by now a well established discipline with regard to applied methodology and systematic classification of acquired scientific information. Only by integrating modern medicine with the medicine of human beings of the past can both disciplines draw fruitful and bilateral knowledge contributions. This work aims to demonstrate that paleopathological research of ancient human remains can provide very interesting information to clinical studies and investigations as concerns the pathology of chronic lymphedema. Many aspects involving Lymphology and Phlebology are often tackled in daily clinical practice. The close correlation between lymphatic system and venous circulation begins as early as during embryo development. When, during inflammation processes, lymphothrombosis or prolonged lymphangiospasm prevent lymphatics from properly draining into the interstitial space, perivenous lymphangitis is likely to develop affecting vasa lymphatica vasorum. When these conditions persist, tissues begin to become fibrotic, with subsequent increase in wall thickness and stiffness of deep, communicating, and superficial vein branches. All these conditions together can, in turn, stimulate a subperiosteal bone reaction in those areas where the vessel runs close to the periosteum, with no muscle or fibrous fascial tissue in between. Bone imprints are thus formed, as if a mould were taken of vascular structures. Through a retrospective study of current patients with phlebolymphedema, axial tomography scans could be assessed again, thus proving the presence of similar lesions. Bone imprints of vascular origin have thus always proved to be associated with chronic vessel inflammation and to be a consequence of this condition.",
keywords = "Paleopathology, Periostitis, Phlebolymphedema, Vascular lesions",
author = "E. Fulcheri and S. Boccone and F. Boccardo and S. Valdevit and C. Campisi",
year = "2006",
language = "English",
volume = "16",
pages = "21--28",
journal = "European Journal of Lymphology and Related Problems",
issn = "0778-5569",
publisher = "European Group of Lymphology",
number = "47",

}

TY - JOUR

T1 - Osseous lesions in chronic phlebolymphedema

T2 - Pathological pattern identification in modern man and in ancient human remains

AU - Fulcheri, E.

AU - Boccone, S.

AU - Boccardo, F.

AU - Valdevit, S.

AU - Campisi, C.

PY - 2006

Y1 - 2006

N2 - Paleopathology is by now a well established discipline with regard to applied methodology and systematic classification of acquired scientific information. Only by integrating modern medicine with the medicine of human beings of the past can both disciplines draw fruitful and bilateral knowledge contributions. This work aims to demonstrate that paleopathological research of ancient human remains can provide very interesting information to clinical studies and investigations as concerns the pathology of chronic lymphedema. Many aspects involving Lymphology and Phlebology are often tackled in daily clinical practice. The close correlation between lymphatic system and venous circulation begins as early as during embryo development. When, during inflammation processes, lymphothrombosis or prolonged lymphangiospasm prevent lymphatics from properly draining into the interstitial space, perivenous lymphangitis is likely to develop affecting vasa lymphatica vasorum. When these conditions persist, tissues begin to become fibrotic, with subsequent increase in wall thickness and stiffness of deep, communicating, and superficial vein branches. All these conditions together can, in turn, stimulate a subperiosteal bone reaction in those areas where the vessel runs close to the periosteum, with no muscle or fibrous fascial tissue in between. Bone imprints are thus formed, as if a mould were taken of vascular structures. Through a retrospective study of current patients with phlebolymphedema, axial tomography scans could be assessed again, thus proving the presence of similar lesions. Bone imprints of vascular origin have thus always proved to be associated with chronic vessel inflammation and to be a consequence of this condition.

AB - Paleopathology is by now a well established discipline with regard to applied methodology and systematic classification of acquired scientific information. Only by integrating modern medicine with the medicine of human beings of the past can both disciplines draw fruitful and bilateral knowledge contributions. This work aims to demonstrate that paleopathological research of ancient human remains can provide very interesting information to clinical studies and investigations as concerns the pathology of chronic lymphedema. Many aspects involving Lymphology and Phlebology are often tackled in daily clinical practice. The close correlation between lymphatic system and venous circulation begins as early as during embryo development. When, during inflammation processes, lymphothrombosis or prolonged lymphangiospasm prevent lymphatics from properly draining into the interstitial space, perivenous lymphangitis is likely to develop affecting vasa lymphatica vasorum. When these conditions persist, tissues begin to become fibrotic, with subsequent increase in wall thickness and stiffness of deep, communicating, and superficial vein branches. All these conditions together can, in turn, stimulate a subperiosteal bone reaction in those areas where the vessel runs close to the periosteum, with no muscle or fibrous fascial tissue in between. Bone imprints are thus formed, as if a mould were taken of vascular structures. Through a retrospective study of current patients with phlebolymphedema, axial tomography scans could be assessed again, thus proving the presence of similar lesions. Bone imprints of vascular origin have thus always proved to be associated with chronic vessel inflammation and to be a consequence of this condition.

KW - Paleopathology

KW - Periostitis

KW - Phlebolymphedema

KW - Vascular lesions

UR - http://www.scopus.com/inward/record.url?scp=78649879407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649879407&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:78649879407

VL - 16

SP - 21

EP - 28

JO - European Journal of Lymphology and Related Problems

JF - European Journal of Lymphology and Related Problems

SN - 0778-5569

IS - 47

ER -