Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles

Brian P. Sanders, Giuseppe Orlando, Andrea Peloso, Ravi S. Katari, Samy S. Iskandar, Alan C. Farney, Jeffrey Rogers, Shay Soker, Robert J. Stratta

Research output: Contribution to journalArticlepeer-review


We report the sixth case of osseous metaplasia that has occurred in the last 5 years, after a deceaseddonor renal transplant was performed on a young man. While its clinical significance is unclear and probably irrelevant, osseous metaplasia is one of the most relevant principles of regenerative medicine, where every bodily district contains progenitor cells that can generate cells specific to the germ layer from which they come. After the Case Report, we review the literature and speculate on the underlying pathophysiology of osseous metaplasia. Available data seem to support the hypothesis that osteogenic precursor cells, inducing factors, and a suitable environment are key for osseous metaplasia.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalExperimental and Clinical Transplantation
Issue number4
Publication statusPublished - 2014


  • Biopsy
  • Osseous metaplasia
  • Regenerative medicine
  • Renal transplant

ASJC Scopus subject areas

  • Transplantation
  • Medicine(all)


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