Abstract
AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.
METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.
CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 494-503 |
| Number of pages | 10 |
| Journal | Histopathology |
| Volume | 74 |
| Issue number | 3 |
| DOIs | |
| Publication status | E-pub ahead of print - Aug 28 2018 |
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Keywords
- grading
- osteoblastoma
- osteosarcoma
- prognosis
Cite this
Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma? / Gambarotti, Marco; Dei Tos, A P; Vanel, Daniel; Picci, Piero; Gibertoni, D; Klein, M J; Righi, Alberto.
In: Histopathology, Vol. 74, No. 3, 28.08.2018, p. 494-503.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?
AU - Gambarotti, Marco
AU - Dei Tos, A P
AU - Vanel, Daniel
AU - Picci, Piero
AU - Gibertoni, D
AU - Klein, M J
AU - Righi, Alberto
N1 - This article is protected by copyright. All rights reserved.
PY - 2018/8/28
Y1 - 2018/8/28
N2 - AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.
AB - AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.
KW - grading
KW - osteoblastoma
KW - osteosarcoma
KW - prognosis
U2 - 10.1111/his.13746
DO - 10.1111/his.13746
M3 - Article
C2 - 30152881
VL - 74
SP - 494
EP - 503
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 3
ER -