Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?

Marco Gambarotti, A P Dei Tos, Daniel Vanel, Piero Picci, D Gibertoni, M J Klein, Alberto Righi

Research output: Contribution to journalArticle

Abstract

AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.

METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.

CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)494-503
Number of pages10
JournalHistopathology
Volume74
Issue number3
DOIs
Publication statusE-pub ahead of print - Aug 28 2018

Fingerprint

Osteoblastoma
Osteosarcoma
Disease-Free Survival

Keywords

  • grading
  • osteoblastoma
  • osteosarcoma
  • prognosis

Cite this

Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma? / Gambarotti, Marco; Dei Tos, A P; Vanel, Daniel; Picci, Piero; Gibertoni, D; Klein, M J; Righi, Alberto.

In: Histopathology, Vol. 74, No. 3, 28.08.2018, p. 494-503.

Research output: Contribution to journalArticle

Gambarotti, M, Dei Tos, AP, Vanel, D, Picci, P, Gibertoni, D, Klein, MJ & Righi, A 2018, 'Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?', Histopathology, vol. 74, no. 3, pp. 494-503. https://doi.org/10.1111/his.13746
Gambarotti M, Dei Tos AP, Vanel D, Picci P, Gibertoni D, Klein MJ et al. Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma? Histopathology. 2018 Aug 28;74(3):494-503. https://doi.org/10.1111/his.13746
Gambarotti, Marco ; Dei Tos, A P ; Vanel, Daniel ; Picci, Piero ; Gibertoni, D ; Klein, M J ; Righi, Alberto. / Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?. In: Histopathology. 2018 ; Vol. 74, No. 3. pp. 494-503.
@article{8b44a896d0b4488585ebc9daad4583e2,
title = "Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?",
abstract = "AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1{\%} of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.",
keywords = "grading, osteoblastoma, osteosarcoma, prognosis",
author = "Marco Gambarotti and {Dei Tos}, {A P} and Daniel Vanel and Piero Picci and D Gibertoni and Klein, {M J} and Alberto Righi",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = "8",
day = "28",
doi = "10.1111/his.13746",
language = "English",
volume = "74",
pages = "494--503",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Osteoblastoma-like osteosarcoma: High-grade or low-grade osteosarcoma?

AU - Gambarotti, Marco

AU - Dei Tos, A P

AU - Vanel, Daniel

AU - Picci, Piero

AU - Gibertoni, D

AU - Klein, M J

AU - Righi, Alberto

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/8/28

Y1 - 2018/8/28

N2 - AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.

AB - AIMS: Osteoblastoma-like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current WHO classification osteoblastoma-like osteosarcoma is classified within the group of conventional (high-grade) osteosarcomas. However, several published cases have been actually regarded as low-grade malignant tumors. Since strict morphologic criteria to distinguish between low-grade and high-grade lesions are not available we reviewed our series of osteoblastoma-like osteosarcomas in the attempt to identify clinical and morphologic features predictive of aggressiveness.METHODS AND RESULTS: We retrieved 15 cases of osteoblastoma-like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis, and 5 patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while 4 patients died of their disease. Statistical analysis revealed a statistically significant (p = 0.048) lower disease-free survival in patients with areas of conventional (high-grade) osteosarcoma.CONCLUSIONS: With the important limitation of small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma. This article is protected by copyright. All rights reserved.

KW - grading

KW - osteoblastoma

KW - osteosarcoma

KW - prognosis

U2 - 10.1111/his.13746

DO - 10.1111/his.13746

M3 - Article

VL - 74

SP - 494

EP - 503

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 3

ER -