Osteocalcin is angiogenic in vivo

Francesco Paolo Cantatore, Enrico Crivellato, Beatrice Nico, Domenico Ribatti

Research output: Contribution to journalArticle


The exact function of osteocalcin (OC), a protein synthesized by osteoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti-angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF-2, a well-known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalCell Biology International
Issue number7
Publication statusPublished - Jul 2005



  • Angiogenesis
  • Bone repair
  • Chorioallantoic membrane
  • Osteocalcin

ASJC Scopus subject areas

  • Cell Biology

Cite this

Cantatore, F. P., Crivellato, E., Nico, B., & Ribatti, D. (2005). Osteocalcin is angiogenic in vivo. Cell Biology International, 29(7), 583-585. https://doi.org/10.1016/j.cellbi.2005.03.011