Osteocalcin is angiogenic in vivo

Francesco Paolo Cantatore, Enrico Crivellato, Beatrice Nico, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

The exact function of osteocalcin (OC), a protein synthesized by osteoblasts during the matrix mineralization phase, is still unknown. In this study we investigated the capacity of OC to promote vasoproliferation in chick embryo chorioallantoic membrane (CAM), a well established in vivo assay for angiogenesis and anti-angiogenesis. The results showed that OC stimulates angiogenesis and that the response is similar to that obtained with FGF-2, a well-known angiogenic cytokine. It has previously been demonstrated that OC is involved in bone repair, so the angiogenic activity reported here might also play a crucial role in bone formation.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalCell Biology International
Volume29
Issue number7
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Angiogenesis
  • Bone repair
  • Chorioallantoic membrane
  • Osteocalcin

ASJC Scopus subject areas

  • Cell Biology

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