Osteogenesis induced by autologous bone marrow cells transplant in the pediatric skull

Francesco Velardi, Paolina R. Amante, Maurizio Caniglia, Giulio De Rossi, Pier Gaglini, Giancarlo Isacchi, Paolo Palma, E. Emidio Procaccini, Francesco Zinno

Research output: Contribution to journalArticlepeer-review


Background and purpose: The ability of cranial bone to repair defects of continuity is limited and it is mostly dependent on the age of the patient. In infancy and in early pediatric age, the scarce thickness of the calvarial bones and the need for a harmonic development of the child's skull limit the application of most of the surgical procedures usually utilized in older patients. We tested the ability of mononucleated cells, derived from the patient's bone marrow and transplanted on the site of the cranial bone defect, to increase the rate of mineralization of the autologous osteogenesis to obtain the complete restoration of the skull continuity. Method: Four children, aged 26, 28, 37, and 79 months, respectively, affected by a stabilized and persistent cranial bone defect of posttraumatic or postsurgical origin, were treated. A sandwich-shaped shell, made of extrused absorbable polylactic copolymers material, was used to hold in place a freeze-dried mineralized collagen matrix associated with a nonceramic hydroxyapatite scaffold, where autologous bone marrow mononucleated cells were inseminated. Results: In all patients, a rapid autologous bone osteogenesis was observed with a clear dimensional reduction of the bone defect few months after the autologous bone marrow cells seeding. Conclusions: The preliminary results of this research suggest the use of autologous bone marrow cells to increase the autologous osteogenesis in early pediatric age in cases in which correction of skull bone defects is best realized with autologous bone.

Original languageEnglish
Pages (from-to)1158-1166
Number of pages9
JournalChild's Nervous System
Issue number9
Publication statusPublished - Sep 2006


  • Autologous bone growth induction
  • Autologous bone marrow transplantation
  • Guided bone regeneration
  • Hydroxyapatite scaffolds
  • Pediatric skull repair
  • Polylactic acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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