Osteoinduction by chitosan-complexed BMP: Morpho-structural responses in an osteoporotic model

R. A A Muzzarelli, G. Biagini, M. Mattioli Belmonte, O. Talassi, M. G. Gandolfi, R. Solmi, S. Carraro, R. Giardino, M. Fini, N. Nicoli-Aldini

Research output: Contribution to journalArticlepeer-review

Abstract

Bone quality is the result of a complex relationship between bone mass, bone structure, and mechanical characteristics of these individual components. The mass of bone tissue is affected by nutritional factors and other causes, such as bone growth factors like bone morphogenetic proteins (BMPs). Since chitosans promote ordered regeneration of soft tissue and osteoinduction, an osteoporotic model was studied to evaluate the pattern of bone regeneration in the presence of BMP linked to chitosan. BMP was released from the chitosan matrix as a consequence of chitosan biodegradation. Our data show that the association of BMP with chitosan seemed to improve the bone tissue regeneration in a surgical bone defect. This result provides validity to biochemical approaches for therapeutical correction of afflictions in the elderly, such as osteoporosis.

Original languageEnglish
Pages (from-to)321-329
Number of pages9
JournalJournal of Bioactive and Compatible Polymers
Volume12
Issue number4
Publication statusPublished - Oct 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

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