Osteoinduction by chitosan-complexed BMP: Morpho-structural responses in an osteoporotic model

R. A A Muzzarelli; G. Biagini; M. Mattioli Belmonte; O. Talassi; M. G. Gandolfi; R. Solmi; S. Carraro; R. Giardino; M. Fini; N. Nicoli-Aldini

Osteoinduction by chitosan-complexed BMP: Morpho-structural responses in an osteoporotic model

R. A A Muzzarelli, G. Biagini, M. Mattioli Belmonte, O. Talassi, M. G. Gandolfi, R. Solmi, S. Carraro, R. Giardino, M. Fini, N. Nicoli-Aldini

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Bone quality is the result of a complex relationship between bone mass, bone structure, and mechanical characteristics of these individual components. The mass of bone tissue is affected by nutritional factors and other causes, such as bone growth factors like bone morphogenetic proteins (BMPs). Since chitosans promote ordered regeneration of soft tissue and osteoinduction, an osteoporotic model was studied to evaluate the pattern of bone regeneration in the presence of BMP linked to chitosan. BMP was released from the chitosan matrix as a consequence of chitosan biodegradation. Our data show that the association of BMP with chitosan seemed to improve the bone tissue regeneration in a surgical bone defect. This result provides validity to biochemical approaches for therapeutical correction of afflictions in the elderly, such as osteoporosis.

Original language	English
Pages (from-to)	321-329
Number of pages	9
Journal	Journal of Bioactive and Compatible Polymers
Volume	12
Issue number	4
Publication status	Published - Oct 1997

ASJC Scopus subject areas

Biotechnology
Biomaterials
Materials Chemistry
Polymers and Plastics

Cite this

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title = "Osteoinduction by chitosan-complexed BMP: Morpho-structural responses in an osteoporotic model",

abstract = "Bone quality is the result of a complex relationship between bone mass, bone structure, and mechanical characteristics of these individual components. The mass of bone tissue is affected by nutritional factors and other causes, such as bone growth factors like bone morphogenetic proteins (BMPs). Since chitosans promote ordered regeneration of soft tissue and osteoinduction, an osteoporotic model was studied to evaluate the pattern of bone regeneration in the presence of BMP linked to chitosan. BMP was released from the chitosan matrix as a consequence of chitosan biodegradation. Our data show that the association of BMP with chitosan seemed to improve the bone tissue regeneration in a surgical bone defect. This result provides validity to biochemical approaches for therapeutical correction of afflictions in the elderly, such as osteoporosis.",

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T2 - Morpho-structural responses in an osteoporotic model

AU - Muzzarelli, R. A A

AU - Biagini, G.

AU - Mattioli Belmonte, M.

AU - Talassi, O.

AU - Gandolfi, M. G.

AU - Solmi, R.

AU - Carraro, S.

AU - Giardino, R.

AU - Fini, M.

AU - Nicoli-Aldini, N.

PY - 1997/10

Y1 - 1997/10

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AB - Bone quality is the result of a complex relationship between bone mass, bone structure, and mechanical characteristics of these individual components. The mass of bone tissue is affected by nutritional factors and other causes, such as bone growth factors like bone morphogenetic proteins (BMPs). Since chitosans promote ordered regeneration of soft tissue and osteoinduction, an osteoporotic model was studied to evaluate the pattern of bone regeneration in the presence of BMP linked to chitosan. BMP was released from the chitosan matrix as a consequence of chitosan biodegradation. Our data show that the association of BMP with chitosan seemed to improve the bone tissue regeneration in a surgical bone defect. This result provides validity to biochemical approaches for therapeutical correction of afflictions in the elderly, such as osteoporosis.

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Osteoinduction by chitosan-complexed BMP: Morpho-structural responses in an osteoporotic model

Abstract

ASJC Scopus subject areas

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