Osteoinduction in the presence of chitosan-coated porous hydroxyapatite

M. Mattioli-Belmonte, G. Biagini, R. A A Muzzarelli, C. Castaldini, M. G. Gandolfi, A. Krajewski, A. Ravaglioli, M. Fini, R. Giardino

Research output: Contribution to journalArticlepeer-review


Hydroxyapatite nails, prepared according to a novel method and endowed with better mechanical resistance, were coated with chitosan to impart enhanced biocompatibility and were introduced in the femurs of rabbits. Chitosan was found to be a favorable interface between bone and hydroxyapatite because it promoted an osteoconductive reaction.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalJournal of Bioactive and Compatible Polymers
Issue number3
Publication statusPublished - Jul 1995

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics


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