Osteointegration of bioactive glass-coated and uncoated zirconia in osteopenic bone: An in vivo experimental study

N. Nicoli Aldini, M. Fini, G. Giavaresi, L. Martini, B. Dubini, M. G Ponzi Bossi, F. Rustichelli, A. Krajewski, A. Ravaglioli, M. Mazzocchi, R. Giardino

Research output: Contribution to journalArticlepeer-review


In elderly and osteoporotic patients an age-related loss of osteoinductivity could be the biological cause of implant failure regardless of the high quality of the implanted device. yttria stabilized tetragonal zirconia (YSTZ), either coated with the bioactive glass named RKKP bioglaze® (RKKP) or uncoated, was implanted in the distal femurs of sham-operated and ovariectomized female rats. Animals were sacrificed at 30 and 60 days. Histomorphometry and microhardness tests were performed to assess osteointegration rate as well as bone quality around the implants. Significant decreases (p <0.0005) in trabecular bone volume, BV/TV (41%), trabecular bone surface BS/TV (33%), trabecular thickness Tb.Th (20%), and trabecular number Tb.N (32%), together with a significant increase in trabecular separation Tb.Sp (184%), were found for the osteopenic rats compared with the sham-operated rats. At both experimental times the RKKP coating ensured a better osteointegration rate with higher AI values than the uncoated YSTZ, even when osteopenic rats were used (48% at 30 days and 12% at 60 days). No differences were observed at the bone-biomaterial interfaces for either material when comparing sham-operated with osteopenic rats. The present results demonstrate that the RKKP bioactive glass used as a coating ensures a high osteointegration rate even in osteoporotic bone, which is already visible from postoperative day 30 and is still apparent on day 60.

Original languageEnglish
Pages (from-to)264-272
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Issue number2
Publication statusPublished - Feb 1 2004


  • Animal model
  • Bioactive glass
  • Osteointegration
  • Osteoporosis
  • Zirconia

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials


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