Osteointegration of bioactive glass-coated zirconia in healthy bone: An in vivo evaluation

V. Stanic, N. Nicoli Aldini, M. Fini, G. Giavaresi, R. Giardino, A. Krajewski, A. Ravaglioli, M. Mazzocchi, B. Dubini, M. G. Ponzi Bossi, F. Rustichelli

Research output: Contribution to journalArticlepeer-review


Osteointegration of yttria stabilised tetragonal zirconia (YSTZ), either coated with bioactive glass named RKKP bioglaze® (RKKP®) or uncoated, was evaluated in an animal model. RKKP®-coated and uncoated (controls) YSTZ cylinders were implanted in the distal femoral epiphyses of 14 Sprague Dawley rats under general anaesthesia. At the experimental times of 30 and 60 days after sacrifice, histomorphometry and SEM microanalysis were performed on methylmethacrylate-embedded undecalcified sections to determine the osteointegration rate. At 30 days, a significantly higher affinity index was demonstrated in vivo by histomorphometric evaluation in RKKP®-coated versus uncoated YSTZ implants (p

Original languageEnglish
Pages (from-to)3833-3841
Number of pages9
Issue number18
Publication statusPublished - 2002


  • Bioactive glass
  • Ceramics
  • Osteointegration
  • Zirconia

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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