Osteointegration of hydroxyapatite-coated and uncoated titanium screws in long-term ovariectomized sheep

Michele Rocca, Milena Fini, Gianluca Giavaresi, Nicolò Nicoli Aldini, Roberto Giardino

Research output: Contribution to journalArticle

Abstract

This study was designed to evaluate the osteointegration of HA-coated and uncoated titanium screws in the cortical bone of long-term (24 months) ovariectomized sheep (OVX group) compared to sham-aged sheep (Control group). At 12 weeks after implantation, the screws were tested biomechanically (extraction torque) and histomorphometrically (affinity index: AI) in both femoral and tibial diaphyses. Cancellous bone status was assessed by iliac crest biopsy. BMD of the L5 vertebra and a histomorphological study of the femoral and tibial shafts were performed to acquire data on cortical bone. A significant difference was found between the OVX and Control groups for BMD (p

Original languageEnglish
Pages (from-to)1017-1023
Number of pages7
JournalBiomaterials
Volume23
Issue number4
DOIs
Publication statusPublished - Feb 15 2002

Keywords

  • Hydroxyapatite
  • Osteointegration
  • Osteoporosis
  • Ovariectomy
  • Sheep
  • Titanium

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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