Osteointegration of hydroxyapatite-coated and uncoated titanium screws in long-term ovariectomized sheep

Michele Rocca; Milena Fini; Gianluca Giavaresi; Nicolò Nicoli Aldini; Roberto Giardino

doi:10.1016/S0142-9612(01)00213-7

Osteointegration of hydroxyapatite-coated and uncoated titanium screws in long-term ovariectomized sheep

Michele Rocca, Milena Fini, Gianluca Giavaresi, Nicolò Nicoli Aldini, Roberto Giardino

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article

Abstract

This study was designed to evaluate the osteointegration of HA-coated and uncoated titanium screws in the cortical bone of long-term (24 months) ovariectomized sheep (OVX group) compared to sham-aged sheep (Control group). At 12 weeks after implantation, the screws were tested biomechanically (extraction torque) and histomorphometrically (affinity index: AI) in both femoral and tibial diaphyses. Cancellous bone status was assessed by iliac crest biopsy. BMD of the L5 vertebra and a histomorphological study of the femoral and tibial shafts were performed to acquire data on cortical bone. A significant difference was found between the OVX and Control groups for BMD (p

Original language	English
Pages (from-to)	1017-1023
Number of pages	7
Journal	Biomaterials
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/S0142-9612(01)00213-7
Publication status	Published - Feb 15 2002

Keywords

Hydroxyapatite
Osteointegration
Osteoporosis
Ovariectomy
Sheep
Titanium

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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Rocca, M., Fini, M., Giavaresi, G., Nicoli Aldini, N., & Giardino, R. (2002). Osteointegration of hydroxyapatite-coated and uncoated titanium screws in long-term ovariectomized sheep. Biomaterials, 23(4), 1017-1023. https://doi.org/10.1016/S0142-9612(01)00213-7

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AU - Giardino, Roberto

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