Abstract
This study was designed to evaluate the osteointegration of HA-coated and uncoated titanium screws in the cortical bone of long-term (24 months) ovariectomized sheep (OVX group) compared to sham-aged sheep (Control group). At 12 weeks after implantation, the screws were tested biomechanically (extraction torque) and histomorphometrically (affinity index: AI) in both femoral and tibial diaphyses. Cancellous bone status was assessed by iliac crest biopsy. BMD of the L5 vertebra and a histomorphological study of the femoral and tibial shafts were performed to acquire data on cortical bone. A significant difference was found between the OVX and Control groups for BMD (p
Original language | English |
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Pages (from-to) | 1017-1023 |
Number of pages | 7 |
Journal | Biomaterials |
Volume | 23 |
Issue number | 4 |
DOIs | |
Publication status | Published - Feb 15 2002 |
Keywords
- Hydroxyapatite
- Osteointegration
- Osteoporosis
- Ovariectomy
- Sheep
- Titanium
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering