Osteonecrosis after allogeneic stem cell transplantation in childhood. A case-control study in Italy

Maura Faraci, Maria Grazia Calevo, Edoardo Lanino, Silvia Caruso, Chiara Messina, Claudio Favre, Anna Iori, Stella Santaron, Sonia Bonanomi, Roberto Rondelli, Giorgio Dini, Riccardo Haupt

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Abstract

A case-control study was conducted among Italian children treated with a stem cell transplant (SCT). Cases (n=43) were allogeneic recipients with osteonecrosis, and the controls (n=129) were matched to the corresponding cases on the basis of survival, SCT center and date of transplant. Univariate analysis showed that older age at SCT (OR 1.39; 95% CI 1.24-1.57), total body irradiation (TBI) (OR 5.73; 95% CI 2.38-13.83), chronic graft-versus-host disease (GvHD) (OR 4.31; 95% CI 2.05-9.07), and duration of steroid treatment after SCT (OR 1.118; 95% CI 1.034-1.209) were statistically correlated with osteonecrosis. However, multivariate analysis revealed that the only factors that were significantly associated with osteonecrosis were older age at SCT (p=0.0001), TBI (p=0.001) and chronicGvHD (p=0.001).

Original languageEnglish
Pages (from-to)1096-1099
Number of pages4
JournalHaematologica
Volume91
Issue number8
Publication statusPublished - Aug 2006

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Keywords

  • Allogeneic stem cell transplantation
  • GvHD
  • Osteonecrosis
  • Steroid

ASJC Scopus subject areas

  • Hematology

Cite this

Faraci, M., Calevo, M. G., Lanino, E., Caruso, S., Messina, C., Favre, C., Iori, A., Santaron, S., Bonanomi, S., Rondelli, R., Dini, G., & Haupt, R. (2006). Osteonecrosis after allogeneic stem cell transplantation in childhood. A case-control study in Italy. Haematologica, 91(8), 1096-1099.