Osteonecrosis in protease inhibitor-treated patients

P. Bonfanti, A. Gabbuti, S. Carradori, L. Pusterla, F. Parazzini, S. Landonio, T. Quirino

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The introduction of protease inhibitors has proven a watershed in human immunodeficiency virus infection therapy and has initiated an era of highly active anti-retroviral therapy. However, the numerous data on the effectiveness of these therapeutic regimens have been cited with an ever-growing number of communications concerning adverse reactions. In particular, the widescale use of protease inhibitors has underlined a series of events not evidenced in the controlled clinical studies that permitted the registration of these drugs. We are conducting a cohort multicenter study to evaluate the incidence of adverse events during treatment with protease inhibitors. To date, 4 cases of bilateral osteonecrosis of the femoral head have been reported out of 1073 person-years. While the pathogenesis of this event is unclear, it may be a long-term complication of protease inhibitor treatment.

Original languageEnglish
Pages (from-to)271-272
Number of pages2
JournalOrthopedics
Volume24
Issue number3
Publication statusPublished - 2001

Fingerprint

Osteonecrosis
Protease Inhibitors
Therapeutics
Virus Diseases
Thigh
Multicenter Studies
Cohort Studies
Communication
HIV
Incidence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Bonfanti, P., Gabbuti, A., Carradori, S., Pusterla, L., Parazzini, F., Landonio, S., & Quirino, T. (2001). Osteonecrosis in protease inhibitor-treated patients. Orthopedics, 24(3), 271-272.

Osteonecrosis in protease inhibitor-treated patients. / Bonfanti, P.; Gabbuti, A.; Carradori, S.; Pusterla, L.; Parazzini, F.; Landonio, S.; Quirino, T.

In: Orthopedics, Vol. 24, No. 3, 2001, p. 271-272.

Research output: Contribution to journalArticle

Bonfanti, P, Gabbuti, A, Carradori, S, Pusterla, L, Parazzini, F, Landonio, S & Quirino, T 2001, 'Osteonecrosis in protease inhibitor-treated patients', Orthopedics, vol. 24, no. 3, pp. 271-272.
Bonfanti P, Gabbuti A, Carradori S, Pusterla L, Parazzini F, Landonio S et al. Osteonecrosis in protease inhibitor-treated patients. Orthopedics. 2001;24(3):271-272.
Bonfanti, P. ; Gabbuti, A. ; Carradori, S. ; Pusterla, L. ; Parazzini, F. ; Landonio, S. ; Quirino, T. / Osteonecrosis in protease inhibitor-treated patients. In: Orthopedics. 2001 ; Vol. 24, No. 3. pp. 271-272.
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