Abstract
The introduction of protease inhibitors has proven a watershed in human immunodeficiency virus infection therapy and has initiated an era of highly active anti-retroviral therapy. However, the numerous data on the effectiveness of these therapeutic regimens have been cited with an ever-growing number of communications concerning adverse reactions. In particular, the widescale use of protease inhibitors has underlined a series of events not evidenced in the controlled clinical studies that permitted the registration of these drugs. We are conducting a cohort multicenter study to evaluate the incidence of adverse events during treatment with protease inhibitors. To date, 4 cases of bilateral osteonecrosis of the femoral head have been reported out of 1073 person-years. While the pathogenesis of this event is unclear, it may be a long-term complication of protease inhibitor treatment.
Original language | English |
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Pages (from-to) | 271-272 |
Number of pages | 2 |
Journal | Orthopedics |
Volume | 24 |
Issue number | 3 |
Publication status | Published - 2001 |
ASJC Scopus subject areas
- Surgery
- Orthopedics and Sports Medicine