TY - JOUR
T1 - Osteopathic manual treatment for amyotrophic lateral sclerosis
T2 - A feasibility pilot study
AU - Maggiani, Alberto
AU - Tremolizzo, Lucio
AU - Valentina, Andrea Della
AU - Mapelli, Laurent
AU - Sosio, Silvia
AU - Milano, Valeria
AU - Bianchi, Manuel
AU - Badi, Francesco
AU - Lavazza, Carolina
AU - Grandini, Marco
AU - Corna, Giovanni
AU - Prometti, Paola
AU - Lunetta, Christian
AU - Riva, Nilo
AU - Ferri, Alessandra
AU - Lanfranconi, Francesca
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach. Objective: Primary aim of this pilot work assessed feasibility, safety, tolerability and satisfaction of osteopathic manual treatment (OMT) in 14 ALS outpatients. Methods: Patients were randomized according to an initial single-blind design (12 weeks, T0-T1), in order to receive OMT (weekly for 4 weeks, and fortnightly for the following 8 weeks) versus usual-care (n=7 each group), followed by an OMT open period (T1-T2, once a week for 8 weeks, n=10). Secondary aims included blind osteopathic assessment of somatic dysfunctions (SD) for goal attainment scale (GAS) calculation, Brief Pain Inventory-short form and McGill QoL-16 items. Results: OMT was demonstrated feasible and safe and patients displayed high satisfaction (T1-VAS=8.34 ± 0.46; T2-VAS=8.52 ± 0.60). Considering secondary aims no significant differences emerged. Finally, at study entry (T0), a cervico-dorsal SD was found in 78% of ALS patients versus 28% of healthy matched controls (p<0.01). Conclusion: OMT was found feasible, safe and satisfactory in ALS. The lack of secondary aim differences can be due to the limited sample size. OMT could be an interesting option to explore in ALS.
AB - Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach. Objective: Primary aim of this pilot work assessed feasibility, safety, tolerability and satisfaction of osteopathic manual treatment (OMT) in 14 ALS outpatients. Methods: Patients were randomized according to an initial single-blind design (12 weeks, T0-T1), in order to receive OMT (weekly for 4 weeks, and fortnightly for the following 8 weeks) versus usual-care (n=7 each group), followed by an OMT open period (T1-T2, once a week for 8 weeks, n=10). Secondary aims included blind osteopathic assessment of somatic dysfunctions (SD) for goal attainment scale (GAS) calculation, Brief Pain Inventory-short form and McGill QoL-16 items. Results: OMT was demonstrated feasible and safe and patients displayed high satisfaction (T1-VAS=8.34 ± 0.46; T2-VAS=8.52 ± 0.60). Considering secondary aims no significant differences emerged. Finally, at study entry (T0), a cervico-dorsal SD was found in 78% of ALS patients versus 28% of healthy matched controls (p<0.01). Conclusion: OMT was found feasible, safe and satisfactory in ALS. The lack of secondary aim differences can be due to the limited sample size. OMT could be an interesting option to explore in ALS.
KW - Amyotrophic lateral sclerosis
KW - Feasibility
KW - Osteopathic manual treatment
KW - Pilot trial
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U2 - 10.2174/1874205X01610010059
DO - 10.2174/1874205X01610010059
M3 - Article
VL - 10
SP - 59
EP - 66
JO - Open Neurology Journal
JF - Open Neurology Journal
SN - 1874-205X
ER -