Osteopontin is increased in the cerebrospinal fluid of patients with Alzheimer's disease and its levels correlate with cognitive decline

Cristoforo Comi, Miryam Carecchio, Annalisa Chiocchetti, Stefania Nicola, Daniela Galimberti, Chiara Fenoglio, Giuseppe Cappellano, Francesco Monaco, Elio Scarpini, Umberto Dianzani

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases (≤ 2 years). These findings support a role of OPN in AD pathogenesis.

Original languageEnglish
Pages (from-to)1143-1148
Number of pages6
JournalJournal of Alzheimer's Disease
Volume19
Issue number4
DOIs
Publication statusPublished - 2010

Fingerprint

Osteopontin
Cerebrospinal Fluid
Alzheimer Disease
Frontotemporal Dementia
Macrophage Activation
Cognitive Dysfunction
Inflammation
Serum

Keywords

  • Disease progression
  • Early Alzheimer's disease
  • Eta-1
  • Microglia
  • Neuroinflammation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Osteopontin is increased in the cerebrospinal fluid of patients with Alzheimer's disease and its levels correlate with cognitive decline. / Comi, Cristoforo; Carecchio, Miryam; Chiocchetti, Annalisa; Nicola, Stefania; Galimberti, Daniela; Fenoglio, Chiara; Cappellano, Giuseppe; Monaco, Francesco; Scarpini, Elio; Dianzani, Umberto.

In: Journal of Alzheimer's Disease, Vol. 19, No. 4, 2010, p. 1143-1148.

Research output: Contribution to journalArticle

Comi, Cristoforo ; Carecchio, Miryam ; Chiocchetti, Annalisa ; Nicola, Stefania ; Galimberti, Daniela ; Fenoglio, Chiara ; Cappellano, Giuseppe ; Monaco, Francesco ; Scarpini, Elio ; Dianzani, Umberto. / Osteopontin is increased in the cerebrospinal fluid of patients with Alzheimer's disease and its levels correlate with cognitive decline. In: Journal of Alzheimer's Disease. 2010 ; Vol. 19, No. 4. pp. 1143-1148.
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