Osteopontin is not a specific marker in malignant pleural mesothelioma

Laura Paleari, Nicola Rotolo, Andrea Imperatori, Roberto Puzone, Fausto Sessa, Francesca Franzi, Elisa Meacci, Pierpaolo Camplese, Alfredo Cesario, Michela Paganuzzi

Research output: Contribution to journalArticle

Abstract

Background and aims: Osteopontin (OPN) is an integrin-binding protein recently shown to be related to tumorigenesis, progression and metastasis in different experimental models of malignancy. Malignant pleural mesothelioma (MPM) is a fatal disease in which the prognosis remains very poor and the knowledge of predictive factors for outcome is insufficient. The identification of new molecules involved in cancer initiation and development is a fundamental step for improving the curability of this kind of tumor. The purpose of this study is to define the role of OPN in the diagnosis of MPM by determining its prognostic and diagnostic value. Methods: A group of 24 surgically staged MPM subjects was compared with a group of 31 subjects with nonmalignant pulmonary diseases, and with 37 healthy controls. Tumor tissue was analyzed for OPN by immunohistochemical tests, and plasma OPN levels were measured by an enzyme-linked immunosorbent assay. Results: Plasma OPN levels were not significantly higher in either of the patient groups compared with the control group. Immunohistochemical analysis revealed OPN staining of tumor cells in 21 of 24 MPMs. Receiver operating characteristic curve/area under the curve (ROC/AUC) analysis comparing the plasma OPN levels in the healthy group with those of MPM patients showed 40% sensitivity and 100% specificity at a cutoff value of 60.8 ng of OPN per milliliter (AUC 0.6). Conclusion: Plasma OPN levels do not discriminate between chronic inflammatory and malignant lung diseases and staining intensity in MPM specimens does not correlate with OPN plasma levels.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalInternational Journal of Biological Markers
Volume24
Issue number2
Publication statusPublished - 2009

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Keywords

  • Lung diseases
  • Malignant pleural mesothelioma
  • Marker
  • Osteopontin

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Paleari, L., Rotolo, N., Imperatori, A., Puzone, R., Sessa, F., Franzi, F., Meacci, E., Camplese, P., Cesario, A., & Paganuzzi, M. (2009). Osteopontin is not a specific marker in malignant pleural mesothelioma. International Journal of Biological Markers, 24(2), 112-117.