Osteoporosis: Diagnosis with lateral and posteroanterior dual x-ray absorptiometry compared with quantitative CT

Giuseppe Guglielmi, Susan K. Grimston, Keith C. Fischer, Roberto Pacifici

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To compare the diagnostic sensitivity of posteroanterior and lateral dual x-ray absorptiometry (PA-DXA, L-DXA, respectively) and quantitative computed tomography (CT). MATERIALS AND METHODS: Among 108 women undergoing lumbar spine bone mineral density assessment, 66 were healthy (mean age, 52.9 years ± 1.2 [standard error of mean]) and 42 had osteoporosis (mean age, 66.9 years ± 1.2). RESULTS: Although both L-DXA and PA-DXA correlated well with quantitative CT (r = .73 and .72, respectively; P <.0001), L-DXA correlated better than PA-DXA with age (r = -.69 and -.50, respectively; P <.0001). Women with osteoporosis showed higher bone loss with quantitative CT (1.33% per year) and L-DXA (0.3% per year) than with PA- DXA (0.07% per year). Logistic regression analysis indicated that quantitative CT and L-DXA but not PA-DXA are significant predictors of osteoporotic fractures. Receiver-operating-characteristic curve analyses showed L-DXA to have a sensitivity and specificity closer to those of quantitative CT than did PA-DXA. CONCLUSION: Performance of L-DXA helped discriminate better than PA-DXA between healthy subjects and those with osteoporosis.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalRadiology
Volume192
Issue number3
Publication statusPublished - Sep 1994

Keywords

  • Bones, absorptiometry
  • Computed tomography (CT), quantitative
  • Osteoporosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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