Osteosarcoma associated with hyperparathyroidism

Paul C. Jutte, Renato Rosso, Massimiliano de Paolis, Costatino Errani, Elisabetta Pasini, Laura Campanacci, Gaetano Bacci, Franco Bertoni, Mario Mercuri

Research output: Contribution to journalArticlepeer-review

Abstract

The fourth case in the literature is presented of a patient with the rare association of hyperparathyroidism and osteosarcoma. A 56-year-old woman presented with hyperparathyroidism and a lesion in the tibia. Initial diagnosis was brown tumor. Histology, however, revealed osteosarcoma, and the patient was treated accordingly. The experimental induction of osteosarcoma by parathormone in rodent studies makes this finding alarming, considering, the increasing use of parathormone in the treatment of osteoporosis. The mechanism by which osteosarcoma is induced in humans cannot be explained based on current knowledge of mechanisms of action of parathyroid hormones.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalSkeletal Radiology
Volume33
Issue number8
Publication statusPublished - Aug 2004

Keywords

  • Hyperparathyroidism
  • Osteosarcoma
  • Parathormone
  • Radiographs

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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