Abstract
Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.
| Original language | English |
|---|---|
| Pages (from-to) | 332-340 |
| Number of pages | 9 |
| Journal | European Journal of Surgical Oncology |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 2004 |
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Keywords
- Bone neoplasms
- Chemotherapy
- Margins
- Osteosarcoma
- Pelvic surgery
- Tumour recurrence
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Osteosarcoma of the pelvis. / Donati, Davide; Giacomini, S.; Gozzi, E.; Ferrari, S.; Sangiorgi, L.; Tienghi, A.; DeGroot, H.; Bertoni, F.; Bacchini, P.; Bacci, G.; Mercuri, M.
In: European Journal of Surgical Oncology, Vol. 30, No. 3, 04.2004, p. 332-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Osteosarcoma of the pelvis
AU - Donati, Davide
AU - Giacomini, S.
AU - Gozzi, E.
AU - Ferrari, S.
AU - Sangiorgi, L.
AU - Tienghi, A.
AU - DeGroot, H.
AU - Bertoni, F.
AU - Bacchini, P.
AU - Bacci, G.
AU - Mercuri, M.
PY - 2004/4
Y1 - 2004/4
N2 - Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.
AB - Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.
KW - Bone neoplasms
KW - Chemotherapy
KW - Margins
KW - Osteosarcoma
KW - Pelvic surgery
KW - Tumour recurrence
UR - http://www.scopus.com/inward/record.url?scp=12144286433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12144286433&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2003.12.004
DO - 10.1016/j.ejso.2003.12.004
M3 - Article
C2 - 15028318
AN - SCOPUS:12144286433
VL - 30
SP - 332
EP - 340
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 3
ER -