Osteosarcoma of the pelvis

Davide Donati, S. Giacomini, E. Gozzi, S. Ferrari, L. Sangiorgi, A. Tienghi, H. DeGroot, F. Bertoni, P. Bacchini, G. Bacci, M. Mercuri

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.

Original languageEnglish
Pages (from-to)332-340
Number of pages9
JournalEuropean Journal of Surgical Oncology
Volume30
Issue number3
DOIs
Publication statusPublished - Apr 2004

Fingerprint

Osteosarcoma
Pelvis
Hemipelvectomy
Amputation
Sacroiliac Joint
Sciatic Nerve
Neoplasms
Necrosis
Guidelines
Neoplasm Metastasis
Recurrence
Drug Therapy

Keywords

  • Bone neoplasms
  • Chemotherapy
  • Margins
  • Osteosarcoma
  • Pelvic surgery
  • Tumour recurrence

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Donati, D., Giacomini, S., Gozzi, E., Ferrari, S., Sangiorgi, L., Tienghi, A., ... Mercuri, M. (2004). Osteosarcoma of the pelvis. European Journal of Surgical Oncology, 30(3), 332-340. https://doi.org/10.1016/j.ejso.2003.12.004

Osteosarcoma of the pelvis. / Donati, Davide; Giacomini, S.; Gozzi, E.; Ferrari, S.; Sangiorgi, L.; Tienghi, A.; DeGroot, H.; Bertoni, F.; Bacchini, P.; Bacci, G.; Mercuri, M.

In: European Journal of Surgical Oncology, Vol. 30, No. 3, 04.2004, p. 332-340.

Research output: Contribution to journalArticle

Donati, D, Giacomini, S, Gozzi, E, Ferrari, S, Sangiorgi, L, Tienghi, A, DeGroot, H, Bertoni, F, Bacchini, P, Bacci, G & Mercuri, M 2004, 'Osteosarcoma of the pelvis', European Journal of Surgical Oncology, vol. 30, no. 3, pp. 332-340. https://doi.org/10.1016/j.ejso.2003.12.004
Donati, Davide ; Giacomini, S. ; Gozzi, E. ; Ferrari, S. ; Sangiorgi, L. ; Tienghi, A. ; DeGroot, H. ; Bertoni, F. ; Bacchini, P. ; Bacci, G. ; Mercuri, M. / Osteosarcoma of the pelvis. In: European Journal of Surgical Oncology. 2004 ; Vol. 30, No. 3. pp. 332-340.
@article{d00159e8236c4409be676e03466a4e96,
title = "Osteosarcoma of the pelvis",
abstract = "Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3{\%}): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.",
keywords = "Bone neoplasms, Chemotherapy, Margins, Osteosarcoma, Pelvic surgery, Tumour recurrence",
author = "Davide Donati and S. Giacomini and E. Gozzi and S. Ferrari and L. Sangiorgi and A. Tienghi and H. DeGroot and F. Bertoni and P. Bacchini and G. Bacci and M. Mercuri",
year = "2004",
month = "4",
doi = "10.1016/j.ejso.2003.12.004",
language = "English",
volume = "30",
pages = "332--340",
journal = "European Journal of Surgical Oncology",
issn = "0748-7983",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Osteosarcoma of the pelvis

AU - Donati, Davide

AU - Giacomini, S.

AU - Gozzi, E.

AU - Ferrari, S.

AU - Sangiorgi, L.

AU - Tienghi, A.

AU - DeGroot, H.

AU - Bertoni, F.

AU - Bacchini, P.

AU - Bacci, G.

AU - Mercuri, M.

PY - 2004/4

Y1 - 2004/4

N2 - Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.

AB - Aims. To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment. Methods. We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint. Results. Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive. Conclusion. The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.

KW - Bone neoplasms

KW - Chemotherapy

KW - Margins

KW - Osteosarcoma

KW - Pelvic surgery

KW - Tumour recurrence

UR - http://www.scopus.com/inward/record.url?scp=12144286433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12144286433&partnerID=8YFLogxK

U2 - 10.1016/j.ejso.2003.12.004

DO - 10.1016/j.ejso.2003.12.004

M3 - Article

C2 - 15028318

AN - SCOPUS:12144286433

VL - 30

SP - 332

EP - 340

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

SN - 0748-7983

IS - 3

ER -