Abstract
A prior osteoporotic femoral neck fracture (FNF) doubles the risk of a second, contralateral hip fracture. Pharmacological prevention of osteoporotic fractures is cost-effective but medication compliance and persistence rates are suboptimal. The aim of our study was to evaluate the safety and effectiveness of a device developed for the surgical prevention of an additional contralateral FNF in elderly osteoporotic patients. Only patients with a T score ≤ -2.5 were enrolled and randomized either to receive (Group A) or not receive (Group B) surgical prevention. Sixty-seven patients were enrolled. The mean follow-up was 16 months (range 1 to 22). To date, no contralateral FNF has been reported in either group. In Group A, no device-related complications were recorded. Twelve patients reported one or more falls and in four cases a non-femoral fragility fracture occurred. The main problem with pharmacological prevention is therapy adherence and the extensive period needed for only a slight improvement in bone strength. Surgical prevention is a potential solution for avoiding the occurrence of a second contralateral FNF. Nevertheless, a longer follow-up and a larger cohort of patients is necessary in order to verify the true effectiveness of the surgical prevention in elderly osteoporotic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 51-54 |
| Number of pages | 4 |
| Journal | Clinical Cases in Mineral and Bone Metabolism |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - Jan 2011 |
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Keywords
- Femoral neck fractures
- Osteoporosis
- Surgical prevention
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
Osteosynthetic improvement of osteoporotic bone : Prevention surgery. / Giannini, Sandro; Luciani, Deianira; Chiarello, Eugenio; Cadossi, Matteo; Tedesco, Giuseppe; Hoque, Martha; Gnudi, Saverio.
In: Clinical Cases in Mineral and Bone Metabolism, Vol. 8, No. 1, 01.2011, p. 51-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Osteosynthetic improvement of osteoporotic bone
T2 - Prevention surgery
AU - Giannini, Sandro
AU - Luciani, Deianira
AU - Chiarello, Eugenio
AU - Cadossi, Matteo
AU - Tedesco, Giuseppe
AU - Hoque, Martha
AU - Gnudi, Saverio
PY - 2011/1
Y1 - 2011/1
N2 - A prior osteoporotic femoral neck fracture (FNF) doubles the risk of a second, contralateral hip fracture. Pharmacological prevention of osteoporotic fractures is cost-effective but medication compliance and persistence rates are suboptimal. The aim of our study was to evaluate the safety and effectiveness of a device developed for the surgical prevention of an additional contralateral FNF in elderly osteoporotic patients. Only patients with a T score ≤ -2.5 were enrolled and randomized either to receive (Group A) or not receive (Group B) surgical prevention. Sixty-seven patients were enrolled. The mean follow-up was 16 months (range 1 to 22). To date, no contralateral FNF has been reported in either group. In Group A, no device-related complications were recorded. Twelve patients reported one or more falls and in four cases a non-femoral fragility fracture occurred. The main problem with pharmacological prevention is therapy adherence and the extensive period needed for only a slight improvement in bone strength. Surgical prevention is a potential solution for avoiding the occurrence of a second contralateral FNF. Nevertheless, a longer follow-up and a larger cohort of patients is necessary in order to verify the true effectiveness of the surgical prevention in elderly osteoporotic patients.
AB - A prior osteoporotic femoral neck fracture (FNF) doubles the risk of a second, contralateral hip fracture. Pharmacological prevention of osteoporotic fractures is cost-effective but medication compliance and persistence rates are suboptimal. The aim of our study was to evaluate the safety and effectiveness of a device developed for the surgical prevention of an additional contralateral FNF in elderly osteoporotic patients. Only patients with a T score ≤ -2.5 were enrolled and randomized either to receive (Group A) or not receive (Group B) surgical prevention. Sixty-seven patients were enrolled. The mean follow-up was 16 months (range 1 to 22). To date, no contralateral FNF has been reported in either group. In Group A, no device-related complications were recorded. Twelve patients reported one or more falls and in four cases a non-femoral fragility fracture occurred. The main problem with pharmacological prevention is therapy adherence and the extensive period needed for only a slight improvement in bone strength. Surgical prevention is a potential solution for avoiding the occurrence of a second contralateral FNF. Nevertheless, a longer follow-up and a larger cohort of patients is necessary in order to verify the true effectiveness of the surgical prevention in elderly osteoporotic patients.
KW - Femoral neck fractures
KW - Osteoporosis
KW - Surgical prevention
UR - http://www.scopus.com/inward/record.url?scp=79959468758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959468758&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79959468758
VL - 8
SP - 51
EP - 54
JO - Clinical Cases in Mineral and Bone Metabolism
JF - Clinical Cases in Mineral and Bone Metabolism
SN - 1724-8914
IS - 1
ER -