Osteosynthetic improvement of osteoporotic bone: Prevention surgery

Sandro Giannini, Deianira Luciani, Eugenio Chiarello, Matteo Cadossi, Giuseppe Tedesco, Martha Hoque, Saverio Gnudi

Research output: Contribution to journalArticle

Abstract

A prior osteoporotic femoral neck fracture (FNF) doubles the risk of a second, contralateral hip fracture. Pharmacological prevention of osteoporotic fractures is cost-effective but medication compliance and persistence rates are suboptimal. The aim of our study was to evaluate the safety and effectiveness of a device developed for the surgical prevention of an additional contralateral FNF in elderly osteoporotic patients. Only patients with a T score ≤ -2.5 were enrolled and randomized either to receive (Group A) or not receive (Group B) surgical prevention. Sixty-seven patients were enrolled. The mean follow-up was 16 months (range 1 to 22). To date, no contralateral FNF has been reported in either group. In Group A, no device-related complications were recorded. Twelve patients reported one or more falls and in four cases a non-femoral fragility fracture occurred. The main problem with pharmacological prevention is therapy adherence and the extensive period needed for only a slight improvement in bone strength. Surgical prevention is a potential solution for avoiding the occurrence of a second contralateral FNF. Nevertheless, a longer follow-up and a larger cohort of patients is necessary in order to verify the true effectiveness of the surgical prevention in elderly osteoporotic patients.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalClinical Cases in Mineral and Bone Metabolism
Volume8
Issue number1
Publication statusPublished - Jan 2011

Fingerprint

Femoral Neck Fractures
Bone and Bones
Medication Adherence
Pharmacology
Equipment and Supplies
Osteoporotic Fractures
Hip Fractures
Safety
Costs and Cost Analysis
Therapeutics

Keywords

  • Femoral neck fractures
  • Osteoporosis
  • Surgical prevention

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Giannini, S., Luciani, D., Chiarello, E., Cadossi, M., Tedesco, G., Hoque, M., & Gnudi, S. (2011). Osteosynthetic improvement of osteoporotic bone: Prevention surgery. Clinical Cases in Mineral and Bone Metabolism, 8(1), 51-54.

Osteosynthetic improvement of osteoporotic bone : Prevention surgery. / Giannini, Sandro; Luciani, Deianira; Chiarello, Eugenio; Cadossi, Matteo; Tedesco, Giuseppe; Hoque, Martha; Gnudi, Saverio.

In: Clinical Cases in Mineral and Bone Metabolism, Vol. 8, No. 1, 01.2011, p. 51-54.

Research output: Contribution to journalArticle

Giannini, S, Luciani, D, Chiarello, E, Cadossi, M, Tedesco, G, Hoque, M & Gnudi, S 2011, 'Osteosynthetic improvement of osteoporotic bone: Prevention surgery', Clinical Cases in Mineral and Bone Metabolism, vol. 8, no. 1, pp. 51-54.
Giannini S, Luciani D, Chiarello E, Cadossi M, Tedesco G, Hoque M et al. Osteosynthetic improvement of osteoporotic bone: Prevention surgery. Clinical Cases in Mineral and Bone Metabolism. 2011 Jan;8(1):51-54.
Giannini, Sandro ; Luciani, Deianira ; Chiarello, Eugenio ; Cadossi, Matteo ; Tedesco, Giuseppe ; Hoque, Martha ; Gnudi, Saverio. / Osteosynthetic improvement of osteoporotic bone : Prevention surgery. In: Clinical Cases in Mineral and Bone Metabolism. 2011 ; Vol. 8, No. 1. pp. 51-54.
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