Otoneurological findings in human immunodeficiency virus positive patients

R. Teggi, N. Ceserani, F. Lira Luce, A. Lazzarin, M. Bussi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To investigate vestibular function in human immunodeficiency virus positive subjects. Methods: We studied vestibular function in 60 human immunodeficiency virus positive subjects reporting dizziness. All three Center for Disease Control and Prevention categories of human immunodeficiency virus infection were represented in the study group (30 patients in class A, 20 in class B and 10 in class C). Subjects had had no previous history of acute vertigo. All subjects underwent: neurotological screening for spontaneous, positional and positioning nystagmus, using head-shaking and head-thrust (Halmagyi) tests; audiometrical examination; and electronystagmography with bithermal stimulation (Freyss' method). The results of the 30 class A subjects were compared with those of 30 human immunodeficiency virus negative patients reporting dizziness. Results: Abnormal otoneurological findings increased progressively from the A to C categories, particularly regarding increased central damage (3.3 per cent of class A, 35 per cent of class B and 100 per cent of class C subjects). In contrast, the incidence of peripheral vestibular disorders remained almost the same, comparing the three categories (33.3 per cent in class A and 50 per cent in classes B and C subjects). Moreover, a higher number of human immunodeficiency virus positive subjects showed abnormal otoneurological findings, compared with the dizzy, human immunodeficiency virus negative subjects. Conclusions: In our opinion, a vestibular disorder may occur in human immunodeficiency virus positive patients as a result of direct viral damage, even in the early phase of infection. Central vestibular damage may be established later on, and may be linked to different causes (e.g. superinfections, vascular causes and drug toxicity).

Original languageEnglish
Pages (from-to)1289-1294
Number of pages6
JournalJournal of Laryngology and Otology
Volume122
Issue number12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

HIV
Dizziness
Head Impulse Test
Electronystagmography
Physiologic Nystagmus
Superinfection
Vertigo
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
Drug-Related Side Effects and Adverse Reactions
Blood Vessels
Head
Incidence
Infection

Keywords

  • HIV
  • Vertigo
  • Vestibular disorders

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Otoneurological findings in human immunodeficiency virus positive patients. / Teggi, R.; Ceserani, N.; Luce, F. Lira; Lazzarin, A.; Bussi, M.

In: Journal of Laryngology and Otology, Vol. 122, No. 12, 12.2008, p. 1289-1294.

Research output: Contribution to journalArticle

Teggi, R. ; Ceserani, N. ; Luce, F. Lira ; Lazzarin, A. ; Bussi, M. / Otoneurological findings in human immunodeficiency virus positive patients. In: Journal of Laryngology and Otology. 2008 ; Vol. 122, No. 12. pp. 1289-1294.
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