Otx genes in neurogenesis of mesencephalic dopaminergic neurons

Antonio Simeone, Eduardo Puelles, Daniela Omodei, Dario Acampora, Luca Giovanni di Giovannantonio, Michela di Salvio, Pietro Mancuso, Carmine Tomasetti

Research output: Contribution to journalArticlepeer-review


Mesencephalic-diencephalic dopaminergic (mdDA) neurons play a relevant role in the control of movement, behavior, and cognition. Indeed loss and/or abnormal functioning of mdDA neurons are responsible for Parkinson's disease as well as for addictive and psychiatric disorders. In the last years a wealth of information has been provided on gene functions controlling identity, fate, and proliferation of mdDA progenitors. This review will focus on the role exerted by Otx genes in early decisions regulating sequential steps required for the neurogenesis of mesencephalic dopaminergic (mesDA) neurons. In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail.

Original languageEnglish
Pages (from-to)665-679
Number of pages15
JournalDevelopmental Neurobiology
Issue number8
Publication statusPublished - Aug 2011


  • Fgf8
  • Mesencephalic dopaminergic differentiation
  • Otx
  • Shh
  • Wnt1

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience


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