Otx genes in the evolution of the vertebrate brain

Dario Acampora, Alessandro Annino, Francesca Tuorto, Eduardo Puelles, Walter Lucchesi, Alessandro Papalia, Antonio Simeone

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Only until a decade ago, animal phylogeny was traditionally based on the assumption that evolution of bilaterians went from simple to complex through gradual steps in which the extant species would represent grades of intermediate complexity that reflect the organizational levels of their ancestors. The advent of more sophisticated molecular biology techniques combined to an increasing variety of functional experiments has provided new tools, which lead us to consider evolutionary studies under a brand new light. An ancestral versus derived low-complexity of a given organism has now to be carefully re-assessed and also the molecular data so far accumulated needs to be re-evaluated. Conserved gene families expressed in the nervous system of all the species have been extensively used to reconstruct evolutionary steps, which may lead to identify the morphological as well as molecular features of the last common ancestor of bilaterians (Urbilateria). The Otx gene family is among these and will be here reviewed.

Original languageEnglish
Pages (from-to)410-420
Number of pages11
JournalBrain Research Bulletin
Volume66
Issue number4-6
DOIs
Publication statusPublished - Sep 15 2005

Fingerprint

Vertebrates
Brain
Phylogeny
Nervous System
Genes
Molecular Biology
Light

Keywords

  • Brain
  • Development
  • Evolution
  • Functional equivalence
  • Otx
  • Urbilateria

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Acampora, D., Annino, A., Tuorto, F., Puelles, E., Lucchesi, W., Papalia, A., & Simeone, A. (2005). Otx genes in the evolution of the vertebrate brain. Brain Research Bulletin, 66(4-6), 410-420. https://doi.org/10.1016/j.brainresbull.2005.02.005

Otx genes in the evolution of the vertebrate brain. / Acampora, Dario; Annino, Alessandro; Tuorto, Francesca; Puelles, Eduardo; Lucchesi, Walter; Papalia, Alessandro; Simeone, Antonio.

In: Brain Research Bulletin, Vol. 66, No. 4-6, 15.09.2005, p. 410-420.

Research output: Contribution to journalArticle

Acampora, D, Annino, A, Tuorto, F, Puelles, E, Lucchesi, W, Papalia, A & Simeone, A 2005, 'Otx genes in the evolution of the vertebrate brain', Brain Research Bulletin, vol. 66, no. 4-6, pp. 410-420. https://doi.org/10.1016/j.brainresbull.2005.02.005
Acampora D, Annino A, Tuorto F, Puelles E, Lucchesi W, Papalia A et al. Otx genes in the evolution of the vertebrate brain. Brain Research Bulletin. 2005 Sep 15;66(4-6):410-420. https://doi.org/10.1016/j.brainresbull.2005.02.005
Acampora, Dario ; Annino, Alessandro ; Tuorto, Francesca ; Puelles, Eduardo ; Lucchesi, Walter ; Papalia, Alessandro ; Simeone, Antonio. / Otx genes in the evolution of the vertebrate brain. In: Brain Research Bulletin. 2005 ; Vol. 66, No. 4-6. pp. 410-420.
@article{9b9548cc9ff742aa8138a1affea5007b,
title = "Otx genes in the evolution of the vertebrate brain",
abstract = "Only until a decade ago, animal phylogeny was traditionally based on the assumption that evolution of bilaterians went from simple to complex through gradual steps in which the extant species would represent grades of intermediate complexity that reflect the organizational levels of their ancestors. The advent of more sophisticated molecular biology techniques combined to an increasing variety of functional experiments has provided new tools, which lead us to consider evolutionary studies under a brand new light. An ancestral versus derived low-complexity of a given organism has now to be carefully re-assessed and also the molecular data so far accumulated needs to be re-evaluated. Conserved gene families expressed in the nervous system of all the species have been extensively used to reconstruct evolutionary steps, which may lead to identify the morphological as well as molecular features of the last common ancestor of bilaterians (Urbilateria). The Otx gene family is among these and will be here reviewed.",
keywords = "Brain, Development, Evolution, Functional equivalence, Otx, Urbilateria",
author = "Dario Acampora and Alessandro Annino and Francesca Tuorto and Eduardo Puelles and Walter Lucchesi and Alessandro Papalia and Antonio Simeone",
year = "2005",
month = "9",
day = "15",
doi = "10.1016/j.brainresbull.2005.02.005",
language = "English",
volume = "66",
pages = "410--420",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
number = "4-6",

}

TY - JOUR

T1 - Otx genes in the evolution of the vertebrate brain

AU - Acampora, Dario

AU - Annino, Alessandro

AU - Tuorto, Francesca

AU - Puelles, Eduardo

AU - Lucchesi, Walter

AU - Papalia, Alessandro

AU - Simeone, Antonio

PY - 2005/9/15

Y1 - 2005/9/15

N2 - Only until a decade ago, animal phylogeny was traditionally based on the assumption that evolution of bilaterians went from simple to complex through gradual steps in which the extant species would represent grades of intermediate complexity that reflect the organizational levels of their ancestors. The advent of more sophisticated molecular biology techniques combined to an increasing variety of functional experiments has provided new tools, which lead us to consider evolutionary studies under a brand new light. An ancestral versus derived low-complexity of a given organism has now to be carefully re-assessed and also the molecular data so far accumulated needs to be re-evaluated. Conserved gene families expressed in the nervous system of all the species have been extensively used to reconstruct evolutionary steps, which may lead to identify the morphological as well as molecular features of the last common ancestor of bilaterians (Urbilateria). The Otx gene family is among these and will be here reviewed.

AB - Only until a decade ago, animal phylogeny was traditionally based on the assumption that evolution of bilaterians went from simple to complex through gradual steps in which the extant species would represent grades of intermediate complexity that reflect the organizational levels of their ancestors. The advent of more sophisticated molecular biology techniques combined to an increasing variety of functional experiments has provided new tools, which lead us to consider evolutionary studies under a brand new light. An ancestral versus derived low-complexity of a given organism has now to be carefully re-assessed and also the molecular data so far accumulated needs to be re-evaluated. Conserved gene families expressed in the nervous system of all the species have been extensively used to reconstruct evolutionary steps, which may lead to identify the morphological as well as molecular features of the last common ancestor of bilaterians (Urbilateria). The Otx gene family is among these and will be here reviewed.

KW - Brain

KW - Development

KW - Evolution

KW - Functional equivalence

KW - Otx

KW - Urbilateria

UR - http://www.scopus.com/inward/record.url?scp=24344433385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24344433385&partnerID=8YFLogxK

U2 - 10.1016/j.brainresbull.2005.02.005

DO - 10.1016/j.brainresbull.2005.02.005

M3 - Article

VL - 66

SP - 410

EP - 420

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 4-6

ER -