OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development

Ramona Palombo, Giovanni Porta, Ernesto Bruno, Paolo Provero, Valeria Serra, Karthik Neduri, Andrea Viziano, Marco Alessandrini, Alessandro Micarelli, Fabrizio Ottaviani, Gerry Melino, Alessandro Terrinoni

Research output: Contribution to journalArticle

Abstract

OTX proteins, homologs of the Drosophila orthodenticle (Otd), are important for the morphogenesis of the neuroectoderm, and for the central nervous system formation. OTX1 and OTX2 are important for the cochlea and macula development, indeed when OTX1 is knocked down, these organs undergo developmental failure. Moreover OTX2 transfection revert this effect in OTX1-/- mice. The TA isoform of TP63, involved in Notch regulation pathway, has a critical function in the cochlear neuroepithelium differentiation. TAp63 positively regulates Hes5 and Atoh1 transcription. This pathway has been also demonstrated in p63-/- mice, and in patients p63 mutated, affected by Ectodermal Dysplasia (ED, OMIM 129810). These patients are affected by mild sensorineural deafness, most likely related to the mutation in p63 gene impairing the Notch pathway. We demonstrated the role of OTX2 on TAp63 regulation necessary for the correct formation of macular neuroepithelium and we confirmed the impairment of vestibular function caused by p63 mutations. Although the abnormalities found in our patient were still at a subclinical extent, aging could exacerbate this impairment and cause a decrease in quality of life.

Original languageEnglish
Pages (from-to)928-936
Number of pages9
JournalAging
Volume7
Issue number11
Publication statusPublished - 2015

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Keywords

  • Cochlea
  • Ectodermal Dysplasia
  • Macula
  • OTX2
  • TAp63

ASJC Scopus subject areas

  • Ageing
  • Cell Biology

Cite this

Palombo, R., Porta, G., Bruno, E., Provero, P., Serra, V., Neduri, K., Viziano, A., Alessandrini, M., Micarelli, A., Ottaviani, F., Melino, G., & Terrinoni, A. (2015). OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development. Aging, 7(11), 928-936.