TY - JOUR
T1 - Ouabain-like factor
T2 - Is this the natriuretic hormone?
AU - Ferrandi, Mara
AU - Manunta, Paolo
PY - 2000
Y1 - 2000
N2 - This review focuses on the most recent data published in the field of the sodium-potassium pump inhibitors regarding the hypothetical structure, the secretory stimuli and the pathophysiological implications for particular diseases, such as hypertension. On the basis of the findings published so far, we reconsider and discuss the 'natriuretic hypothesis for explaining the role of the endogenous sodium-potassium ATPase inhibitor. We propose the ouabain-like factor as a modulator of the renal sodium-potassium pump, that can be considered as a new pharmacological target for hypertension therapy. (C) 2000 Lippincott Williams and Wilkins.
AB - This review focuses on the most recent data published in the field of the sodium-potassium pump inhibitors regarding the hypothetical structure, the secretory stimuli and the pathophysiological implications for particular diseases, such as hypertension. On the basis of the findings published so far, we reconsider and discuss the 'natriuretic hypothesis for explaining the role of the endogenous sodium-potassium ATPase inhibitor. We propose the ouabain-like factor as a modulator of the renal sodium-potassium pump, that can be considered as a new pharmacological target for hypertension therapy. (C) 2000 Lippincott Williams and Wilkins.
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U2 - 10.1097/00041552-200003000-00011
DO - 10.1097/00041552-200003000-00011
M3 - Article
C2 - 10757222
AN - SCOPUS:0034016155
VL - 9
SP - 165
EP - 171
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
SN - 1062-4821
IS - 2
ER -