TY - JOUR
T1 - Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals
AU - Mezzatesta, M. L.
AU - Gona, F.
AU - Caio, C.
AU - Petrolito, V.
AU - Sciortino, D.
AU - Sciacca, A.
AU - Santangelo, C.
AU - Stefani, S.
PY - 2011/9
Y1 - 2011/9
N2 - We report the first outbreak caused by colistin-resistant Klebsiella pneumoniae producing KPC-3 carbapenamase in two Italian hospitals. This spread occurred in 1 month, and was caused by eight colistin-resistant and carbapenem-resistant Klebsiella pneumoniae isolates from eight patients. A further three isolates were obtained from the intestinal tract and pharyngeal colonization. All isolates were multidrug-resistant (MDR), including being resistant to colistin, but they were susceptible to gentamicin and tigecycline. PCR detection showed that all isolates harboured the blaKPC-3 gene associated with blaSHV-11, blaTEM-1 and blaOXA-9. All K. pneumoniae isolates, genotyped by pulsed-field gel electrophoresis and multilocus sequence typing, belonged to the same sequence type (ST)258 clone. From our data and a review of the international literature, K. pneumoniae ST258 seems to be the most widespread genetic background for KPC dissemination in Europe.
AB - We report the first outbreak caused by colistin-resistant Klebsiella pneumoniae producing KPC-3 carbapenamase in two Italian hospitals. This spread occurred in 1 month, and was caused by eight colistin-resistant and carbapenem-resistant Klebsiella pneumoniae isolates from eight patients. A further three isolates were obtained from the intestinal tract and pharyngeal colonization. All isolates were multidrug-resistant (MDR), including being resistant to colistin, but they were susceptible to gentamicin and tigecycline. PCR detection showed that all isolates harboured the blaKPC-3 gene associated with blaSHV-11, blaTEM-1 and blaOXA-9. All K. pneumoniae isolates, genotyped by pulsed-field gel electrophoresis and multilocus sequence typing, belonged to the same sequence type (ST)258 clone. From our data and a review of the international literature, K. pneumoniae ST258 seems to be the most widespread genetic background for KPC dissemination in Europe.
KW - Colistin resistance
KW - Colonization
KW - Klebsiella pneumoniae
KW - KPC-3
KW - ST258
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U2 - 10.1111/j.1469-0691.2011.03572.x
DO - 10.1111/j.1469-0691.2011.03572.x
M3 - Article
C2 - 21668577
AN - SCOPUS:80051877413
VL - 17
SP - 1444
EP - 1447
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
SN - 1198-743X
IS - 9
ER -