Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals

M. L. Mezzatesta, F. Gona, C. Caio, V. Petrolito, D. Sciortino, A. Sciacca, C. Santangelo, S. Stefani

Research output: Contribution to journalArticlepeer-review

Abstract

We report the first outbreak caused by colistin-resistant Klebsiella pneumoniae producing KPC-3 carbapenamase in two Italian hospitals. This spread occurred in 1 month, and was caused by eight colistin-resistant and carbapenem-resistant Klebsiella pneumoniae isolates from eight patients. A further three isolates were obtained from the intestinal tract and pharyngeal colonization. All isolates were multidrug-resistant (MDR), including being resistant to colistin, but they were susceptible to gentamicin and tigecycline. PCR detection showed that all isolates harboured the blaKPC-3 gene associated with blaSHV-11, blaTEM-1 and blaOXA-9. All K. pneumoniae isolates, genotyped by pulsed-field gel electrophoresis and multilocus sequence typing, belonged to the same sequence type (ST)258 clone. From our data and a review of the international literature, K. pneumoniae ST258 seems to be the most widespread genetic background for KPC dissemination in Europe.

Original languageEnglish
Pages (from-to)1444-1447
Number of pages4
JournalClinical Microbiology and Infection
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Colistin resistance
  • Colonization
  • Klebsiella pneumoniae
  • KPC-3
  • ST258

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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