Outbreak of sars-cov-2 lineage 20i/501y.V1 in a nursing home underlines the crucial role of vaccination in both residents and staff

Andrea Orsi, Alexander Domnich, Vanessa De Pace, Valentina Ricucci, Patrizia Caligiuri, Livio Bottiglieri, Rosanna Vagge, Maurizio A. Cavalleri, Francesco Orlandini, Bianca Bruzzone, Giancarlo Icardi

Research output: Contribution to journalArticlepeer-review

Abstract

Elderly residents in nursing homes are at very high risk of life-threatening COVID-19-related outcomes. In this report, an epidemiological and serological investigation of a SARS-CoV-2 outbreak in an Italian nursing home is described. Among the residents, all but one (19/20) were regularly vaccinated against SARS-CoV-2. In mid-February 2021, a non-vaccinated staff member of the nursing home was diagnosed with the SARS-CoV-2 infection. Following the outbreak investigation, a total of 70% (14/20) of residents aged 77–100 years were found positive. The phylogenetic analysis showed that the outbreak was caused by the SARS-CoV-2 variant of concern 202012/01 (the so-called “UK variant”). However, all but one positive subjects (13/14) were fully asymptomatic. The only symptomatic patient was a vaccinated 86-year-old female with a highly compromised health background and deceased approximately two weeks later. The subsequent serological investigation showed that the deceased patient was the only vaccinated subject that did not develop the anti-spike protein antibody response, therefore being likely a vaccine non-responder. Although the available mRNA SARS-CoV-2 vaccine was not able to prevent several asymptomatic infections, it was able to avert most symptomatic disease cases caused by the SARS-CoV-2 variant of concern 202012/01 in nursing home residents.

Original languageEnglish
Article number591
JournalVaccines
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2021

Keywords

  • COVID-19
  • Elderly
  • Italy
  • Nursing home
  • SARS-CoV-2
  • Vaccination

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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