TY - JOUR
T1 - Outbreaks of infectious diseases in stem cell transplant units
T2 - A silent cause of death for patients and transplant programmes
AU - McCann, S.
AU - Byrne, J. L.
AU - Rovira, M.
AU - Shaw, P.
AU - Ribaud, P.
AU - Sica, S.
AU - Volin, L.
AU - Olavarria, E.
AU - Mackinnon, S.
AU - Trabasso, P.
AU - VanLint, M. T.
AU - Ljungman, P.
AU - Ward, K.
AU - Browne, P.
AU - Gratwohl, A.
AU - Widmer, A. F.
AU - Cordonnier, C.
PY - 2004/3
Y1 - 2004/3
N2 - Following the closure of the National Blood and Bone Marrow Transplant Unit in Dublin, because of an outbreak of vancomycin-resistant enterococcal infection, a survey was carried out by the EBMT to investigate the occurrence of outbreaks of infection in SCT units and the impact on patient morbidity, mortality and the administration of the transplant programme over a 10-year period from 1991 to 2001. A total of 13 centres reported 23 outbreaks of infection involving 231 patients: 10 bacterial, eight viral and five fungal outbreaks were reported and 56 deaths were attributed to infection. All fungal and bacterial deaths and the majority of viral deaths occurred in allograft recipients. In all outbreaks, the infection was reported to be hospital acquired and in all the viral, and half the bacterial infections, cross-infection was a major factor. All viral, four of 10 bacterial and three of five fungal outbreaks occurred in HEPA filtered rooms. A total of 12 SCT units reported a partial or total closure. The introduction of mandatory quality management systems such as JACIE should result in a change in attitude to 'incident reporting' and together with future surveys should reduce the incidence of infectious outbreaks in SCT units.
AB - Following the closure of the National Blood and Bone Marrow Transplant Unit in Dublin, because of an outbreak of vancomycin-resistant enterococcal infection, a survey was carried out by the EBMT to investigate the occurrence of outbreaks of infection in SCT units and the impact on patient morbidity, mortality and the administration of the transplant programme over a 10-year period from 1991 to 2001. A total of 13 centres reported 23 outbreaks of infection involving 231 patients: 10 bacterial, eight viral and five fungal outbreaks were reported and 56 deaths were attributed to infection. All fungal and bacterial deaths and the majority of viral deaths occurred in allograft recipients. In all outbreaks, the infection was reported to be hospital acquired and in all the viral, and half the bacterial infections, cross-infection was a major factor. All viral, four of 10 bacterial and three of five fungal outbreaks occurred in HEPA filtered rooms. A total of 12 SCT units reported a partial or total closure. The introduction of mandatory quality management systems such as JACIE should result in a change in attitude to 'incident reporting' and together with future surveys should reduce the incidence of infectious outbreaks in SCT units.
KW - Infectious
KW - Outbreaks
KW - SCT units
UR - http://www.scopus.com/inward/record.url?scp=12144288081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12144288081&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1704380
DO - 10.1038/sj.bmt.1704380
M3 - Article
C2 - 14743201
AN - SCOPUS:12144288081
VL - 33
SP - 519
EP - 529
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 5
ER -